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- W3081667890 abstract "High-grade gliomas are relatively rare and highly aggressive tumors affecting the brain. Despitesignificant research efforts in the last decades, survival for patients with high-grade gliomas is still poor.A number of research outputs have underlined the role of the hypoxic microenvironment on theaggressiveness and resistance to conventional therapies. Several hypoxia-modifying treatments are nowavailable. However, there is an unmet need to bring a non-invasive imaging technique to the clinicalsetting in order to quantify tumor hypoxia and stratify patients with brain tumors based on hypoxiaimaging findings. Oxygen-enhanced Magnetic Resonance Imaging (OE-MRI) appears as an intriguingand promising method to measure tissue hypoxia.The main goal of the two first experimental chapters of this thesis was to investigate the measurabilityand reproducibility of the percentage change of the longitudinal relaxation rate (R1), a commonly usedparameter in OE-MRI studies to quantify tissue oxygenation, in normal brain and brain tumors.In a further study, employing Dynamic contrast-enhanced MRI, we explored the possibility ofcharacterizing different tumor habitat types in patients with high-grade glioma and predict overallsurvival (OS) by means of the analysis of the histogram of the extravascular extracellular volumefraction (ve)." @default.
- W3081667890 created "2020-09-08" @default.
- W3081667890 creator A5031248881 @default.
- W3081667890 date "2019-03-04" @default.
- W3081667890 modified "2023-09-27" @default.
- W3081667890 title "Imaging biomarkers of tissue hypoxia in glioblastoma" @default.
- W3081667890 hasPublicationYear "2019" @default.
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