Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081691789> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W3081691789 abstract "Nicotinic (3-pyridinecarboxylic) acid is one of the most important vitamins as well as substance with versatile physiological activity, since it plays significant role in the human organism. Nicotinic acid (niacin, vitamin PP, vitamin B3) is widely used in medicine as drug which has a vasodilating effect, prevents the accumulation of cholesterol and normalizes the heart function. Isonicotinic (4-pyridinecarboxylic) acid is used for the production of valuable anti-tuberculosis drugs, antidepressants, etc. However, nicotinic and isonicotinic acids have various side effects: skin hyperemia, pruritus, formation of stomach peptic ulcers, liver dysfunction and hyperglycemia. To reduce the severity of side effects, their slightly soluble salts, esters or amides are obtained. The synthesis of nicotinic and isonicotinic acid esters with vanillin benzaldehydes, cholesterol, 8-hydroxyquinoline, quinine and (4,5-dichloroisothiazol-3-yl)methanol is described. Esters were obtained by acylation of hydroxybenzaldehydes and alcohols with nicotinic and isonicotinic acid hydrochlorides in the presence of triethylamine in anhydrous methylene chloride. The IR- UV- and NMR spectra of the compounds obtained are presented." @default.
- W3081691789 created "2020-09-08" @default.
- W3081691789 creator A5018341834 @default.
- W3081691789 creator A5026205112 @default.
- W3081691789 creator A5075255232 @default.
- W3081691789 date "2020-08-29" @default.
- W3081691789 modified "2023-10-11" @default.
- W3081691789 title "Synthesis of functionally substituted esters of nicotinic and isonicotinic acid" @default.
- W3081691789 cites W1965473984 @default.
- W3081691789 cites W2001852502 @default.
- W3081691789 cites W2010047125 @default.
- W3081691789 cites W2076090516 @default.
- W3081691789 cites W2281748379 @default.
- W3081691789 cites W2300510805 @default.
- W3081691789 cites W2750989966 @default.
- W3081691789 cites W2795431397 @default.
- W3081691789 cites W2922413749 @default.
- W3081691789 cites W2980597503 @default.
- W3081691789 cites W3021449755 @default.
- W3081691789 cites W2093278806 @default.
- W3081691789 doi "https://doi.org/10.29235/1561-8331-2020-56-3-301-310" @default.
- W3081691789 hasPublicationYear "2020" @default.
- W3081691789 type Work @default.
- W3081691789 sameAs 3081691789 @default.
- W3081691789 citedByCount "4" @default.
- W3081691789 countsByYear W30816917892020 @default.
- W3081691789 countsByYear W30816917892021 @default.
- W3081691789 countsByYear W30816917892023 @default.
- W3081691789 crossrefType "journal-article" @default.
- W3081691789 hasAuthorship W3081691789A5018341834 @default.
- W3081691789 hasAuthorship W3081691789A5026205112 @default.
- W3081691789 hasAuthorship W3081691789A5075255232 @default.
- W3081691789 hasBestOaLocation W30816917891 @default.
- W3081691789 hasConcept C1122143 @default.
- W3081691789 hasConcept C170493617 @default.
- W3081691789 hasConcept C178790620 @default.
- W3081691789 hasConcept C185592680 @default.
- W3081691789 hasConcept C188987157 @default.
- W3081691789 hasConcept C2775998212 @default.
- W3081691789 hasConcept C2776940978 @default.
- W3081691789 hasConcept C2777854368 @default.
- W3081691789 hasConcept C2780092750 @default.
- W3081691789 hasConcept C2909081349 @default.
- W3081691789 hasConcept C55493867 @default.
- W3081691789 hasConcept C71924100 @default.
- W3081691789 hasConcept C98274493 @default.
- W3081691789 hasConceptScore W3081691789C1122143 @default.
- W3081691789 hasConceptScore W3081691789C170493617 @default.
- W3081691789 hasConceptScore W3081691789C178790620 @default.
- W3081691789 hasConceptScore W3081691789C185592680 @default.
- W3081691789 hasConceptScore W3081691789C188987157 @default.
- W3081691789 hasConceptScore W3081691789C2775998212 @default.
- W3081691789 hasConceptScore W3081691789C2776940978 @default.
- W3081691789 hasConceptScore W3081691789C2777854368 @default.
- W3081691789 hasConceptScore W3081691789C2780092750 @default.
- W3081691789 hasConceptScore W3081691789C2909081349 @default.
- W3081691789 hasConceptScore W3081691789C55493867 @default.
- W3081691789 hasConceptScore W3081691789C71924100 @default.
- W3081691789 hasConceptScore W3081691789C98274493 @default.
- W3081691789 hasLocation W30816917891 @default.
- W3081691789 hasOpenAccess W3081691789 @default.
- W3081691789 hasPrimaryLocation W30816917891 @default.
- W3081691789 hasRelatedWork W10247459 @default.
- W3081691789 hasRelatedWork W17160253 @default.
- W3081691789 hasRelatedWork W17872504 @default.
- W3081691789 hasRelatedWork W18995074 @default.
- W3081691789 hasRelatedWork W19726151 @default.
- W3081691789 hasRelatedWork W22267714 @default.
- W3081691789 hasRelatedWork W31908029 @default.
- W3081691789 hasRelatedWork W32712655 @default.
- W3081691789 hasRelatedWork W36580142 @default.
- W3081691789 hasRelatedWork W500406 @default.
- W3081691789 isParatext "false" @default.
- W3081691789 isRetracted "false" @default.
- W3081691789 magId "3081691789" @default.
- W3081691789 workType "article" @default.