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- W3081702599 endingPage "2025" @default.
- W3081702599 startingPage "2025" @default.
- W3081702599 abstract "Ubiquitination, the post-translational modification essential for various intracellular processes, is implicated in multiple aspects of autophagy, the major lysosome/vacuole-dependent degradation pathway. The autophagy machinery adopted the structural architecture of ubiquitin and employs two ubiquitin-like protein conjugation systems for autophagosome biogenesis. Ubiquitin chains that are attached as labels to protein aggregates or subcellular organelles confer selectivity, allowing autophagy receptors to simultaneously bind ubiquitinated cargos and autophagy-specific ubiquitin-like modifiers (Atg8-family proteins). Moreover, there is tremendous crosstalk between autophagy and the ubiquitin-proteasome system. Ubiquitination of autophagy-related proteins or regulatory components plays significant roles in the precise control of the autophagy pathway. In this review, we summarize and discuss the molecular mechanisms and functions of ubiquitin and ubiquitination, in the process and regulation of autophagy." @default.
- W3081702599 created "2020-09-08" @default.
- W3081702599 creator A5036032268 @default.
- W3081702599 creator A5039817634 @default.
- W3081702599 creator A5050026353 @default.
- W3081702599 creator A5066515392 @default.
- W3081702599 creator A5074173740 @default.
- W3081702599 date "2020-09-02" @default.
- W3081702599 modified "2023-10-11" @default.
- W3081702599 title "The Roles of Ubiquitin in Mediating Autophagy" @default.
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