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• W3081713437 abstract "New clinical genomic assays for lymphoid cancers allow for improved disease stratification and prognostication. At present, clinical implementation has been appropriately limited, owing to a paucity of evidence to support clinical and cost effectiveness. Understanding patients’ values for precision oncology under conditions of uncertainty can be used to inform priority-setting decisions. Our objective was to ascertain patients’ qualitative preferences and attitudes for prognostic-based genomic testing. Individuals who were diagnosed with lymphoid cancer between 2000 and 2018 in British Columbia, Canada, were recruited to participate in one of three focus groups. A maximum variation sampling technique was used to capture a diversity of perspectives. A patient partner was involved in the development of the focus group topic guide and presentation materials. All sessions were audio recorded and analyzed using NVivo qualitative analysis software, version 12. In total, 26 participants took part in focus groups held between November 2018 and February 2019. Results illustrate qualitative preference heterogeneity for situations under which individuals would be willing to undergo genomic testing for relapsed lymphoid cancers. Preferences were highly contextualized within personal experiences with disease and treatment protocols. Hypothetical willingness to pay for testing was contingent on invasiveness, the potential for treatment de-escalation, and personal health benefit. Patients are supportive and accepting of evidentiary uncertainty up until the point at which they are required to trade-off the potential for improved quality and length of life. Demand for precision medicine is contingent on expectations for benefit alongside an acknowledgment of the opportunity cost required for implementation. The clinical implementation of precision medicine will be required to address evidentiary uncertainty surrounding personal benefit while ensuring equitable access to emerging innovations." @default.
• W3081713437 created "2020-09-08" @default.
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• W3081713437 date "2020-09-01" @default.
• W3081713437 modified "2023-09-29" @default.
• W3081713437 title "Genomic Testing for Relapsed and Refractory Lymphoid Cancers: Understanding Patient Values" @default.
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• W3081713437 doi "https://doi.org/10.1007/s40271-020-00448-1" @default.
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