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• W3081738263 endingPage "2000839" @default.
• W3081738263 startingPage "2000839" @default.
• W3081738263 abstract "Oxidised phosphatidylcholines (OxPCs) are produced under conditions of elevated oxidative stress and can contribute to human disease pathobiology. However, their role in allergic asthma is unexplored. The aim of this study was to characterise the OxPC profile in the airways after allergen challenge of people with airway hyperresponsiveness (AHR) or mild asthma. The capacity of OxPCs to contribute to pathobiology associated with asthma was also to be determined. Using bronchoalveolar lavage fluid from two human cohorts, OxPC species were quantified using ultra-high performance liquid chromatography-tandem mass spectrometry. Murine thin-cut lung slices were used to measure airway narrowing caused by OxPCs. Human airway smooth muscle (HASM) cells were exposed to OxPCs to assess concentration-associated changes in inflammatory phenotype and activation of signalling networks. OxPC profiles in the airways were different between people with and without AHR and correlated with methacholine responsiveness. Exposing patients with mild asthma to allergens produced unique OxPC signatures that associated with the severity of the late asthma response. OxPCs dose-dependently induced 15% airway narrowing in murine thin-cut lung slices. In HASM cells, OxPCs dose-dependently increased the biosynthesis of cyclooxygenase-2, interleukin (IL)-6, IL-8, granulocyte−macrophage colony-stimulating factor and the production of oxylipins via protein kinase C-dependent pathways. Data from human cohorts and primary HASM cell culture show that OxPCs are present in the airways, increase after allergen challenge and correlate with metrics of airway dysfunction. Furthermore, OxPCs may contribute to asthma pathobiology by promoting airway narrowing and inducing a pro-inflammatory phenotype and contraction of airway smooth muscle. OxPCs represent a potential novel target for treating oxidative stress-associated pathobiology in asthma." @default.
• W3081738263 created "2020-09-08" @default.
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• W3081738263 date "2020-09-03" @default.
• W3081738263 modified "2023-10-18" @default.
• W3081738263 title "Allergen inhalation generates pro-inflammatory oxidised phosphatidylcholine associated with airway dysfunction" @default.
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• W3081738263 cites W1964991966 @default.
• W3081738263 cites W1965680930 @default.
• W3081738263 cites W1965832300 @default.
• W3081738263 cites W1966197860 @default.
• W3081738263 cites W1969785844 @default.
• W3081738263 cites W1972134778 @default.
• W3081738263 cites W1976599392 @default.
• W3081738263 cites W1976993180 @default.
• W3081738263 cites W1977222014 @default.
• W3081738263 cites W1982342687 @default.
• W3081738263 cites W1991435151 @default.
• W3081738263 cites W1995440419 @default.
• W3081738263 cites W1997057980 @default.
• W3081738263 cites W1997837382 @default.
• W3081738263 cites W1999837239 @default.
• W3081738263 cites W2004074632 @default.
• W3081738263 cites W2007186542 @default.
• W3081738263 cites W2016764257 @default.
• W3081738263 cites W2017429246 @default.
• W3081738263 cites W2018021518 @default.
• W3081738263 cites W2024707552 @default.
• W3081738263 cites W2026277330 @default.
• W3081738263 cites W2034050426 @default.
• W3081738263 cites W2034437011 @default.
• W3081738263 cites W2049746695 @default.
• W3081738263 cites W2055047003 @default.
• W3081738263 cites W2055406348 @default.
• W3081738263 cites W2063116304 @default.
• W3081738263 cites W2063803056 @default.
• W3081738263 cites W2068432532 @default.
• W3081738263 cites W2072031192 @default.
• W3081738263 cites W2088445792 @default.
• W3081738263 cites W2093263274 @default.
• W3081738263 cites W2124673812 @default.
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• W3081738263 cites W2135289253 @default.
• W3081738263 cites W2137121443 @default.
• W3081738263 cites W2138176808 @default.
• W3081738263 cites W2148356965 @default.
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• W3081738263 cites W2149248356 @default.
• W3081738263 cites W2156613610 @default.
• W3081738263 cites W2158487294 @default.
• W3081738263 cites W2158873788 @default.
• W3081738263 cites W2169942235 @default.
• W3081738263 cites W2171107203 @default.
• W3081738263 cites W2188468313 @default.
• W3081738263 cites W2268049636 @default.
• W3081738263 cites W2268531581 @default.
• W3081738263 cites W2343061795 @default.
• W3081738263 cites W2402331083 @default.
• W3081738263 cites W2468517437 @default.
• W3081738263 cites W2523024742 @default.
• W3081738263 cites W2604147277 @default.
• W3081738263 cites W2614730280 @default.
• W3081738263 cites W2734757492 @default.
• W3081738263 cites W2735047363 @default.
• W3081738263 cites W2794112735 @default.
• W3081738263 cites W2802899333 @default.
• W3081738263 cites W2806741586 @default.
• W3081738263 cites W2807667881 @default.
• W3081738263 cites W2902456405 @default.
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• W3081738263 doi "https://doi.org/10.1183/13993003.00839-2020" @default.
• W3081738263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32883680" @default.
• W3081738263 hasPublicationYear "2020" @default.
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