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• W3081754670 abstract "Abstract Inferring adequate kinetic schemes for ion channel gating from ensemble currents is a daunting task due to limited information in the data. We address this problem by using a parallelized Bayesian filter to specify hidden Markov models for current and fluorescence data. We demonstrate the flexibility of this algorithm by including different noise distributions. Our generalized Kalman filter outperforms both a classical Kalman filter and a rate equation approach when applied to patch-clamp data exhibiting realistic open-channel noise. The derived generalization also enables inclusion of orthogonal fluorescence data, making unidentifiable parameters identifiable and increasing the accuracy of the parameter estimates by an order of magnitude. By using Bayesian highest credibility volumes, we found that our approach, in contrast to the rate equation approach, yields a realistic quantification of uncertainty. Furthermore, the Bayesian filter delivers unbiased estimates for a wider range of data quality and identifies parameters which the rate equation approach does not identify. These results also demonstrate the power of assessing the validity of algorithms by Bayesian credibility volumes in general. Finally, we show that our Bayesian filter is more robust against errors induced by either analog filtering before analog-to-digital conversion or by limited time resolution of fluorescence data than a rate equation approach." @default.
• W3081754670 created "2020-09-08" @default.
• W3081754670 creator A5005644365 @default.
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• W3081754670 creator A5041030142 @default.
• W3081754670 creator A5083859775 @default.
• W3081754670 date "2020-04-28" @default.
• W3081754670 modified "2023-09-27" @default.
• W3081754670 title "Bayesian selection of Hidden Markov models for multi-dimensional ion channel data" @default.
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• W3081754670 doi "https://doi.org/10.1101/2020.04.27.029207" @default.
• W3081754670 hasPublicationYear "2020" @default.
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