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- W3081762790 endingPage "234" @default.
- W3081762790 startingPage "207" @default.
- W3081762790 abstract "Abstract DNA replication is a vital process in all living organisms. At each cell division, > 30,000 replication origins are activated in a coordinated manner to ensure the duplication of > 6 billion base pairs of the human genome. During differentiation and development, this program must adapt to changes in chromatin organization and gene transcription: its deregulation can challenge genome stability, which is a leading cause of many diseases including cancers and neurological disorders. Over the past decade, great progress has been made to better understand the mechanisms of DNA replication regulation and how its deregulation challenges genome integrity and leads to human disease. Growing evidence shows that gene transcription has an essential role in shaping the landscape of genome replication, while it is also a major source of endogenous replication stress inducing genome instability. In this review, we discuss the current knowledge on the various mechanisms by which gene transcription can impact on DNA replication, leading to genome instability and human disease." @default.
- W3081762790 created "2020-09-08" @default.
- W3081762790 creator A5013822672 @default.
- W3081762790 creator A5028307488 @default.
- W3081762790 creator A5030758016 @default.
- W3081762790 creator A5079584223 @default.
- W3081762790 date "2020-08-30" @default.
- W3081762790 modified "2023-10-09" @default.
- W3081762790 title "The impact of transcription-mediated replication stress on genome instability and human disease" @default.
- W3081762790 cites W1519389973 @default.
- W3081762790 cites W1547945395 @default.
- W3081762790 cites W1635346580 @default.
- W3081762790 cites W176465738 @default.
- W3081762790 cites W1828408764 @default.
- W3081762790 cites W1902591710 @default.
- W3081762790 cites W1919702696 @default.
- W3081762790 cites W1964068975 @default.
- W3081762790 cites W1964309048 @default.
- W3081762790 cites W1964680558 @default.
- W3081762790 cites W1965218838 @default.
- W3081762790 cites W1965749659 @default.
- W3081762790 cites W1966302019 @default.
- W3081762790 cites W1967814083 @default.
- W3081762790 cites W1969558292 @default.
- W3081762790 cites W1970578083 @default.
- W3081762790 cites W1972011626 @default.
- W3081762790 cites W1974993967 @default.
- W3081762790 cites W1975001355 @default.
- W3081762790 cites W1975993845 @default.
- W3081762790 cites W1976853883 @default.
- W3081762790 cites W1977305809 @default.
- W3081762790 cites W1978947118 @default.
- W3081762790 cites W1982187520 @default.
- W3081762790 cites W1988745695 @default.
- W3081762790 cites W1990347983 @default.
- W3081762790 cites W1990624451 @default.
- W3081762790 cites W1992213203 @default.
- W3081762790 cites W1996425563 @default.
- W3081762790 cites W1997281938 @default.
- W3081762790 cites W1997289911 @default.
- W3081762790 cites W2000384908 @default.
- W3081762790 cites W2000492616 @default.
- W3081762790 cites W2002394441 @default.
- W3081762790 cites W2003128644 @default.
- W3081762790 cites W2005453713 @default.
- W3081762790 cites W2005823642 @default.
- W3081762790 cites W2005962907 @default.
- W3081762790 cites W2006183134 @default.
- W3081762790 cites W2006939802 @default.
- W3081762790 cites W2007214324 @default.
- W3081762790 cites W2010270082 @default.
- W3081762790 cites W2011330486 @default.
- W3081762790 cites W2012838063 @default.
- W3081762790 cites W2012974517 @default.
- W3081762790 cites W2014017809 @default.
- W3081762790 cites W2014607365 @default.
- W3081762790 cites W2019439252 @default.
- W3081762790 cites W2019808923 @default.
- W3081762790 cites W2021881561 @default.
- W3081762790 cites W2023794544 @default.
- W3081762790 cites W2026441062 @default.
- W3081762790 cites W2026842770 @default.
- W3081762790 cites W2031081876 @default.
- W3081762790 cites W2031666034 @default.
- W3081762790 cites W2031816743 @default.
- W3081762790 cites W2033421234 @default.
- W3081762790 cites W2035948519 @default.
- W3081762790 cites W2037032898 @default.
- W3081762790 cites W2038427905 @default.
- W3081762790 cites W2040860750 @default.
- W3081762790 cites W2043745733 @default.
- W3081762790 cites W2044375974 @default.
- W3081762790 cites W2044440192 @default.
- W3081762790 cites W2049576185 @default.
- W3081762790 cites W2049992533 @default.
- W3081762790 cites W2051852464 @default.
- W3081762790 cites W2052215590 @default.
- W3081762790 cites W2053356709 @default.
- W3081762790 cites W2055917646 @default.
- W3081762790 cites W2058070783 @default.
- W3081762790 cites W2058104615 @default.
- W3081762790 cites W2058622161 @default.
- W3081762790 cites W2059328247 @default.
- W3081762790 cites W2059594509 @default.
- W3081762790 cites W2061445402 @default.
- W3081762790 cites W2061449183 @default.
- W3081762790 cites W2062310052 @default.
- W3081762790 cites W2063075008 @default.
- W3081762790 cites W2063743804 @default.
- W3081762790 cites W2063865760 @default.
- W3081762790 cites W2064154094 @default.
- W3081762790 cites W2064234593 @default.
- W3081762790 cites W2064469303 @default.
- W3081762790 cites W2064537118 @default.
- W3081762790 cites W2065779053 @default.
- W3081762790 cites W2066179547 @default.
- W3081762790 cites W2067513312 @default.
- W3081762790 cites W2067573570 @default.