FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081809144> ?p ?o ?g. }

• W3081809144 endingPage "383" @default.
• W3081809144 startingPage "375" @default.
• W3081809144 abstract "MicroRNAs (miRNAs) are recognized as major contributors in various cardiovascular diseases, such as heart failure (HF). These small noncoding RNAs that posttranscriptionally control target genes are involved in regulating different pathophysiological processes including cardiac proliferation, ifferentiation, hypertrophy, and fibrosis. Although carvedilol, a β-adrenergic blocker, and a drug of choice in HF produce cytoprotective actions against cardiomyocyte hypertrophy, the mechanisms are poorly understood. Here we proposed that the expression of hypertrophic-specific miRNAs (miR-1, miR-133, miR-208, and miR-214) might be linked to beneficial effects of carvedilol.The levels of four hypertrophic-specific miRNAs were measured in the sera of 35 patients with systolic HF receiving carvedilol (treated) and 20 HF patients not receiving any β-blockers (untreated) as well as 17 nonHF individuals (healthy) using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Systolic HF was defined as left ventricular ejection fraction <50% by transthoracic echocardiography.We demonstrated that miR-1 and miR-214 were significantly upregulated in the treated group compared to the untreated group (P=0.014 and 5.3-fold, 0.033 and 4.2-fold, respectively). However, miR-133 and miR-208 did not show significant difference in expression between these two study groups. MiR-1 was significantly downregulated in the untreated group compared with healthy individuals (P=0.019 and 0.14-fold).In conclusion, it might be postulated that one of the mechanisms by which carvedilol may exert its cardioprotective effects can be through increasing miR-1 and miR-214 expressions which may also serve as a potential therapeutic target in patients with systolic HF in future." @default.
• W3081809144 created "2020-09-08" @default.
• W3081809144 creator A5013140968 @default.
• W3081809144 creator A5025430819 @default.
• W3081809144 creator A5032223685 @default.
• W3081809144 creator A5080106918 @default.
• W3081809144 creator A5091259859 @default.
• W3081809144 date "2020-09-01" @default.
• W3081809144 modified "2023-10-13" @default.
• W3081809144 title "<p>Carvedilol Alters Circulating MiR-1 and MiR-214 in Heart Failure</p>" @default.
• W3081809144 cites W1500680139 @default.
• W3081809144 cites W1649848679 @default.
• W3081809144 cites W1964536497 @default.
• W3081809144 cites W1967686561 @default.
• W3081809144 cites W1968647871 @default.
• W3081809144 cites W1969143891 @default.
• W3081809144 cites W1974944923 @default.
• W3081809144 cites W1975437957 @default.
• W3081809144 cites W1976875491 @default.
• W3081809144 cites W1978490970 @default.
• W3081809144 cites W1983737226 @default.
• W3081809144 cites W1995139781 @default.
• W3081809144 cites W1999943920 @default.
• W3081809144 cites W2014942570 @default.
• W3081809144 cites W2031846943 @default.
• W3081809144 cites W2051257619 @default.
• W3081809144 cites W2059393812 @default.
• W3081809144 cites W2065449972 @default.
• W3081809144 cites W2068886009 @default.
• W3081809144 cites W2072190764 @default.
• W3081809144 cites W2073537048 @default.
• W3081809144 cites W2073965098 @default.
• W3081809144 cites W2075555195 @default.
• W3081809144 cites W2080696342 @default.
• W3081809144 cites W2081213971 @default.
• W3081809144 cites W2089369921 @default.
• W3081809144 cites W2095634382 @default.
• W3081809144 cites W2096144819 @default.
• W3081809144 cites W2098318517 @default.
• W3081809144 cites W2098863682 @default.
• W3081809144 cites W2106391242 @default.
• W3081809144 cites W2109341154 @default.
• W3081809144 cites W2127254281 @default.
• W3081809144 cites W2129967926 @default.
• W3081809144 cites W2133417114 @default.
• W3081809144 cites W2135858645 @default.
• W3081809144 cites W2137132557 @default.
• W3081809144 cites W2145244611 @default.
• W3081809144 cites W2152865365 @default.
• W3081809144 cites W2158635242 @default.
• W3081809144 cites W2158964360 @default.
• W3081809144 cites W2272054673 @default.
• W3081809144 cites W2290512328 @default.
• W3081809144 cites W2296998040 @default.
• W3081809144 cites W2302231845 @default.
• W3081809144 cites W2335337555 @default.
• W3081809144 cites W2340731691 @default.
• W3081809144 cites W2413893340 @default.
• W3081809144 cites W2542880851 @default.
• W3081809144 cites W2557248654 @default.
• W3081809144 cites W2561569085 @default.
• W3081809144 cites W2572851488 @default.
• W3081809144 cites W2586659364 @default.
• W3081809144 cites W2590744356 @default.
• W3081809144 cites W2608256808 @default.
• W3081809144 cites W2617169112 @default.
• W3081809144 cites W2699220065 @default.
• W3081809144 cites W2779221327 @default.
• W3081809144 cites W2790466920 @default.
• W3081809144 cites W2921663302 @default.
• W3081809144 cites W3023522280 @default.
• W3081809144 cites W3121466 @default.
• W3081809144 cites W52877415 @default.
• W3081809144 cites W1868913231 @default.
• W3081809144 doi "https://doi.org/10.2147/pgpm.s263740" @default.
• W3081809144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7481348" @default.
• W3081809144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32943906" @default.
• W3081809144 hasPublicationYear "2020" @default.
• W3081809144 type Work @default.
• W3081809144 sameAs 3081809144 @default.
• W3081809144 citedByCount "9" @default.
• W3081809144 countsByYear W30818091442022 @default.
• W3081809144 countsByYear W30818091442023 @default.
• W3081809144 crossrefType "journal-article" @default.
• W3081809144 hasAuthorship W3081809144A5013140968 @default.
• W3081809144 hasAuthorship W3081809144A5025430819 @default.
• W3081809144 hasAuthorship W3081809144A5032223685 @default.
• W3081809144 hasAuthorship W3081809144A5080106918 @default.
• W3081809144 hasAuthorship W3081809144A5091259859 @default.
• W3081809144 hasBestOaLocation W30818091441 @default.
• W3081809144 hasConcept C10162356 @default.
• W3081809144 hasConcept C104317684 @default.
• W3081809144 hasConcept C126322002 @default.
• W3081809144 hasConcept C127561419 @default.
• W3081809144 hasConcept C134018914 @default.
• W3081809144 hasConcept C145059251 @default.
• W3081809144 hasConcept C164705383 @default.
• W3081809144 hasConcept C167414201 @default.

• next