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- W3081809528 abstract "ABI-H0731, a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity in chronic hepatitis B (CHB) patients in a phase 1b clinical trial and is currently being further evaluated in phase 2 clinical trials. Here, we report the preclinical profile of ABI-H0731. In in vitro cell culture systems (HepG2-derived cell lines HepAD38 and HepG2-NTCP and primary human hepatocytes [PHHs]), ABI-H0731 exhibited selective inhibition of HBV DNA replication (50% effective concentration [EC 50 ] from 173 nM to 307 nM)." @default.
- W3081809528 created "2020-09-08" @default.
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- W3081809528 date "2020-10-20" @default.
- W3081809528 modified "2023-10-12" @default.
- W3081809528 title "Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731" @default.
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- W3081809528 doi "https://doi.org/10.1128/aac.01463-20" @default.
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