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- W3081817784 endingPage "110593" @default.
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- W3081817784 abstract "We report herein an evaluation of the effect of several mesoporous silica nanoparticles (MSNs) on the cellular uptake and in vitro cytotoxicity in human cells. Bare MSNs and MSNs functionalized with polyethylene glycol or hyaluronic acid are employed to evaluate uptake efficiency and mechanisms of endocytosis in cancer (MDA-MB-231) and non-cancer (MCF10A) cells. Moreover, changes in viability, cell cycle, oxidative stress, and mitochondrial membrane potential are evaluated. Our results confirm that MSNs are internalized efficiently by human cells and that uptake mechanisms differ for cell types and particles. We also confirm that MSNs are biocompatible materials that do not induce ROS/RNS production, nor changes on mitochondrial membrane potential or cell cycle." @default.
- W3081817784 created "2020-09-08" @default.
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- W3081817784 date "2021-01-01" @default.
- W3081817784 modified "2023-10-17" @default.
- W3081817784 title "Biocompatibility and internalization assessment of bare and functionalised mesoporous silica nanoparticles" @default.
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- W3081817784 doi "https://doi.org/10.1016/j.micromeso.2020.110593" @default.
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