FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081872289> ?p ?o ?g. }

• W3081872289 endingPage "113192" @default.
• W3081872289 startingPage "113192" @default.
• W3081872289 abstract "Wu-Zi-Yan-Zong-Wan (WZYZW) is a commonly used Chinese medicinal recipe for oligozoospermia. Oligozoospermia is a common disease that harms human fertility, there is no effective therapeutic medicine at present. However, the underlying pharmacological mechanism remains unclear. Methods: Oligozoospermia rats model induced by Tripterygium glycosides (TG) was established to inspect the efficiency of WZYZW in the treatment of oligozoospermia by traditional pharmacodynamics combined with NMR-based metabolomics. Multivariate statistics were used to extracted the underlying biomarkers and metabolic pathways of WZYZW in the treatment of oligozoospermia. The results showed that TG disturbed many metabolites and metabolic pathways such as oxidative stress (choline, O-phosphocholine, betaine and ascorbate), energy metabolism in mitochondria (glucose, lactate, succinate, fumarate, 3-hydroxybutyrate and alanine), mitochondrial apoptosis markers (Bax and Bcl-2) and amino acids metabolisms (arginine, branched-chain amino acids, taurine and myo-inositol). WZYZW could significantly reverse the disturbed metabolites to their normal status by their abilities of anti-oxidation, anti-apoptosis, balancing the osmotic pressure regulatory molecules and regulating the amino acids metabolism. This study provides pharmacological basis and guidance for the clinical usage of WZYZW." @default.
• W3081872289 created "2020-09-08" @default.
• W3081872289 creator A5006500153 @default.
• W3081872289 creator A5011102119 @default.
• W3081872289 creator A5020415816 @default.
• W3081872289 creator A5042119566 @default.
• W3081872289 creator A5061391281 @default.
• W3081872289 creator A5066266521 @default.
• W3081872289 date "2021-01-01" @default.
• W3081872289 modified "2023-10-18" @default.
• W3081872289 title "NMR-based metabolomics approach to study the effects of Wu-Zi-Yan-Zong-Wan on triptolide-induced oligospermia in rats" @default.
• W3081872289 cites W1508079764 @default.
• W3081872289 cites W1965809650 @default.
• W3081872289 cites W1976599392 @default.
• W3081872289 cites W1986115510 @default.
• W3081872289 cites W1997731166 @default.
• W3081872289 cites W2009100833 @default.
• W3081872289 cites W2011123535 @default.
• W3081872289 cites W2014972719 @default.
• W3081872289 cites W2018210037 @default.
• W3081872289 cites W2020262739 @default.
• W3081872289 cites W2034518377 @default.
• W3081872289 cites W2043644446 @default.
• W3081872289 cites W2058591356 @default.
• W3081872289 cites W2081293740 @default.
• W3081872289 cites W2082149911 @default.
• W3081872289 cites W2083637865 @default.
• W3081872289 cites W2126381957 @default.
• W3081872289 cites W2135308053 @default.
• W3081872289 cites W2136269288 @default.
• W3081872289 cites W2157197240 @default.
• W3081872289 cites W2157256235 @default.
• W3081872289 cites W2160089607 @default.
• W3081872289 cites W2285841986 @default.
• W3081872289 cites W2412742324 @default.
• W3081872289 cites W2609815768 @default.
• W3081872289 cites W2982131777 @default.
• W3081872289 doi "https://doi.org/10.1016/j.jep.2020.113192" @default.
• W3081872289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32889033" @default.
• W3081872289 hasPublicationYear "2021" @default.
• W3081872289 type Work @default.
• W3081872289 sameAs 3081872289 @default.
• W3081872289 citedByCount "6" @default.
• W3081872289 countsByYear W30818722892021 @default.
• W3081872289 countsByYear W30818722892022 @default.
• W3081872289 countsByYear W30818722892023 @default.
• W3081872289 crossrefType "journal-article" @default.
• W3081872289 hasAuthorship W3081872289A5006500153 @default.
• W3081872289 hasAuthorship W3081872289A5011102119 @default.
• W3081872289 hasAuthorship W3081872289A5020415816 @default.
• W3081872289 hasAuthorship W3081872289A5042119566 @default.
• W3081872289 hasAuthorship W3081872289A5061391281 @default.
• W3081872289 hasAuthorship W3081872289A5066266521 @default.
• W3081872289 hasConcept C185592680 @default.
• W3081872289 hasConcept C190283241 @default.
• W3081872289 hasConcept C194671627 @default.
• W3081872289 hasConcept C21565614 @default.
• W3081872289 hasConcept C2776151105 @default.
• W3081872289 hasConcept C2777468819 @default.
• W3081872289 hasConcept C2777477808 @default.
• W3081872289 hasConcept C2779701627 @default.
• W3081872289 hasConcept C2779856020 @default.
• W3081872289 hasConcept C2781079059 @default.
• W3081872289 hasConcept C2781164371 @default.
• W3081872289 hasConcept C515207424 @default.
• W3081872289 hasConcept C55493867 @default.
• W3081872289 hasConcept C60644358 @default.
• W3081872289 hasConcept C71240020 @default.
• W3081872289 hasConcept C86803240 @default.
• W3081872289 hasConcept C98274493 @default.
• W3081872289 hasConceptScore W3081872289C185592680 @default.
• W3081872289 hasConceptScore W3081872289C190283241 @default.
• W3081872289 hasConceptScore W3081872289C194671627 @default.
• W3081872289 hasConceptScore W3081872289C21565614 @default.
• W3081872289 hasConceptScore W3081872289C2776151105 @default.
• W3081872289 hasConceptScore W3081872289C2777468819 @default.
• W3081872289 hasConceptScore W3081872289C2777477808 @default.
• W3081872289 hasConceptScore W3081872289C2779701627 @default.
• W3081872289 hasConceptScore W3081872289C2779856020 @default.
• W3081872289 hasConceptScore W3081872289C2781079059 @default.
• W3081872289 hasConceptScore W3081872289C2781164371 @default.
• W3081872289 hasConceptScore W3081872289C515207424 @default.
• W3081872289 hasConceptScore W3081872289C55493867 @default.
• W3081872289 hasConceptScore W3081872289C60644358 @default.
• W3081872289 hasConceptScore W3081872289C71240020 @default.
• W3081872289 hasConceptScore W3081872289C86803240 @default.
• W3081872289 hasConceptScore W3081872289C98274493 @default.
• W3081872289 hasFunder F4320321001 @default.
• W3081872289 hasLocation W30818722891 @default.
• W3081872289 hasOpenAccess W3081872289 @default.
• W3081872289 hasPrimaryLocation W30818722891 @default.
• W3081872289 hasRelatedWork W1994342907 @default.
• W3081872289 hasRelatedWork W1994401630 @default.
• W3081872289 hasRelatedWork W2127514232 @default.
• W3081872289 hasRelatedWork W2325575762 @default.
• W3081872289 hasRelatedWork W2326998606 @default.
• W3081872289 hasRelatedWork W2388457681 @default.
• W3081872289 hasRelatedWork W2402846865 @default.

• next