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- W3081879876 abstract "Abstract In depth studies of quantitative trait loci (QTL) can provide insights to the genetic architectures of complex traits. A major effect QTL at the distal end of chicken chromosome 1 has been associated with growth traits in multiple populations. This locus was fine-mapped in a fifteen-generation chicken advanced intercross population including 1119 birds and explored in further detail using 222 sequenced genomes from 10 high/low body weight chicken stocks. We detected this QTL that, in total, contributed 14.4% of the genetic variance for growth. Further, nine mosaic precise intervals (Kb level) which contain ancestral regulatory variants were fine-mapped and we chose one of them to demonstrate the key regulatory role in the duodenum. This is the first study to break down the detail genetic architectures for the well-known QTL in chicken and provides a good example of the fine-mapping of various of quantitative traits in any species." @default.
- W3081879876 created "2020-09-08" @default.
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- W3081879876 date "2020-08-28" @default.
- W3081879876 modified "2023-10-10" @default.
- W3081879876 title "Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits" @default.
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- W3081879876 doi "https://doi.org/10.1038/s42003-020-01199-3" @default.
- W3081879876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7455696" @default.
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