Matches in SemOpenAlex for { <https://semopenalex.org/work/W3081900352> ?p ?o ?g. }
- W3081900352 abstract "Abstract Self-assembly of proteins into amyloid fibrils is a hallmark of various diseases, including Alzheimer’s disease (AD) and Type-2 diabetes Mellitus (T2DM). Aggregation of specific peptides, like Aβ42 in AD and hIAPP in T2DM, causes cellular dysfunction resulting in the respective pathology. While these amyloidogenic proteins lack sequence homology, they all contain aromatic amino acids in their hydrophobic core that play a major role in their self-assembly. Targeting these aromatic residues by small molecules may be an attractive approach for inhibiting amyloid aggregation. Here, various biochemical and biophysical techniques revealed that a panel of tryptophan-galactosylamine conjugates significantly inhibit fibril formation of Aβ42 and hIAPP, and disassemble their pre-formed fibrils in a dose-dependent manner. They are also not toxic to mammalian cells and can reduce the cytotoxicity induced by Aβ42 and hIAPP aggregates. These tryptophan-galactosylamine conjugates can therefore serve as a scaffold for the development of therapeutics towards AD and T2DM." @default.
- W3081900352 created "2020-09-08" @default.
- W3081900352 creator A5012649363 @default.
- W3081900352 creator A5037128624 @default.
- W3081900352 creator A5037378514 @default.
- W3081900352 creator A5044166958 @default.
- W3081900352 creator A5072817139 @default.
- W3081900352 creator A5074904216 @default.
- W3081900352 creator A5082716768 @default.
- W3081900352 date "2020-09-02" @default.
- W3081900352 modified "2023-10-15" @default.
- W3081900352 title "Tryptophan-galactosylamine conjugates inhibit and disaggregate amyloid fibrils of Aβ42 and hIAPP peptides while reducing their toxicity" @default.
- W3081900352 cites W1430023774 @default.
- W3081900352 cites W1500540324 @default.
- W3081900352 cites W1542575378 @default.
- W3081900352 cites W1546632170 @default.
- W3081900352 cites W1559033760 @default.
- W3081900352 cites W1574383790 @default.
- W3081900352 cites W1582795354 @default.
- W3081900352 cites W1603607205 @default.
- W3081900352 cites W1965342510 @default.
- W3081900352 cites W1966913739 @default.
- W3081900352 cites W1967239474 @default.
- W3081900352 cites W1969661421 @default.
- W3081900352 cites W1970577444 @default.
- W3081900352 cites W1971844567 @default.
- W3081900352 cites W1978959047 @default.
- W3081900352 cites W1979430872 @default.
- W3081900352 cites W1980458121 @default.
- W3081900352 cites W1985121447 @default.
- W3081900352 cites W1986708002 @default.
- W3081900352 cites W1987066756 @default.
- W3081900352 cites W1988453006 @default.
- W3081900352 cites W1989808640 @default.
- W3081900352 cites W2002676171 @default.
- W3081900352 cites W2004224330 @default.
- W3081900352 cites W2007236469 @default.
- W3081900352 cites W2007504603 @default.
- W3081900352 cites W2012633311 @default.
- W3081900352 cites W2013752460 @default.
- W3081900352 cites W2013780997 @default.
- W3081900352 cites W2015927989 @default.
- W3081900352 cites W2023410591 @default.
- W3081900352 cites W2024518171 @default.
- W3081900352 cites W2025938842 @default.
- W3081900352 cites W2029883685 @default.
- W3081900352 cites W2035062331 @default.
- W3081900352 cites W2038624271 @default.
- W3081900352 cites W2038820333 @default.
- W3081900352 cites W2048940684 @default.
- W3081900352 cites W2049129407 @default.
- W3081900352 cites W2051212454 @default.
- W3081900352 cites W2053438883 @default.
- W3081900352 cites W2058469726 @default.
- W3081900352 cites W2058905986 @default.
- W3081900352 cites W2063737568 @default.
- W3081900352 cites W2065514717 @default.
- W3081900352 cites W2066395642 @default.
- W3081900352 cites W2070114315 @default.
- W3081900352 cites W2073161125 @default.
- W3081900352 cites W2076713412 @default.
- W3081900352 cites W2078052812 @default.
- W3081900352 cites W2078251934 @default.
- W3081900352 cites W2084280842 @default.
- W3081900352 cites W2089464893 @default.
- W3081900352 cites W2094881767 @default.
- W3081900352 cites W2097259690 @default.
- W3081900352 cites W2097503860 @default.
- W3081900352 cites W2107502964 @default.
- W3081900352 cites W2115574704 @default.
- W3081900352 cites W2116893472 @default.
- W3081900352 cites W2132488072 @default.
- W3081900352 cites W2136989779 @default.
- W3081900352 cites W2137204463 @default.
- W3081900352 cites W2137276641 @default.
- W3081900352 cites W2140389587 @default.
- W3081900352 cites W2140389961 @default.
- W3081900352 cites W2142692094 @default.
- W3081900352 cites W2145812954 @default.
- W3081900352 cites W2146185088 @default.
- W3081900352 cites W2148161164 @default.
- W3081900352 cites W2149686195 @default.
- W3081900352 cites W2165186407 @default.
- W3081900352 cites W2168978765 @default.
- W3081900352 cites W2170709967 @default.
- W3081900352 cites W2171747174 @default.
- W3081900352 cites W2217007273 @default.
- W3081900352 cites W2279452326 @default.
- W3081900352 cites W2302110921 @default.
- W3081900352 cites W2315561429 @default.
- W3081900352 cites W2417740547 @default.
- W3081900352 cites W2471485099 @default.
- W3081900352 cites W2529724290 @default.
- W3081900352 cites W2555376992 @default.
- W3081900352 cites W2566720396 @default.
- W3081900352 cites W2568450381 @default.
- W3081900352 cites W2568863654 @default.
- W3081900352 cites W2587309648 @default.
- W3081900352 cites W2603914339 @default.
- W3081900352 cites W2612326057 @default.