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- W3081905599 abstract "Glioblastoma multiforme (GBM) is the deadliest type of brain tumor. The median survival time for patients with GBM is only 15 months, even following maximal surgical resection and chemotherapy and radiation therapy. A genetic biomarker could enable a paradigm shift in precise diagnosis, personalized therapeutics and prognosis. In this study, we employed the Chinese Glioma Genome Atlas, The Cancer Genome Atlas, and the Ivy Glioblastoma Atlas Project databases for RNA sequencing (RNA-seq) analysis and clinicopathological studies. We demonstrated that elevated expression of the RNF7,TCEB1, SOCS1 and SOCS3 genes, which encode components of cullin5-RING E3 ligase (CRL5), predict unfavorable GBM prognoses. In GBM and glioma cases carrying IDH1 mutations, SOCS1 and SOCS3 methylation was increased and their expression was downregulated. This study has thus identified a simple transcriptome signature for GBM prognosis." @default.
- W3081905599 created "2020-09-08" @default.
- W3081905599 creator A5058178626 @default.
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- W3081905599 date "2020-09-14" @default.
- W3081905599 modified "2023-10-10" @default.
- W3081905599 title "Identification of a cullin5-RING E3 ligase transcriptome signature in glioblastoma multiforme" @default.
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- W3081905599 doi "https://doi.org/10.18632/aging.103737" @default.
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