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- W3081938172 abstract "Abstract β cells may participate and contribute to their own demise during Type 1 diabetes (T1D). We identified a novel role of Tet2 in regulating immune killing of β cells. Tet2 is induced in murine and human β cells with inflammation but its expression is reduced in surviving β cells. Tet2-KO mice that receive WT bone marrow transplants develop insulitis but not diabetes and islet infiltrates do not eliminate β cells even though immune cells from the mice can transfer diabetes to NOD/ scid recipients. Tet2-KO β cells show reduced expression of inflammatory genes, associated with closed transcription factor binding sites. Tet2-KO recipients are protected from transfer of disease by diabetogenic immune cells. We conclude that Tet2 regulates pathologic interactions between β cells and immune cells and controls intrinsic protective pathways. Modulating TET2 may enable survival of β cells or their replacements in the setting of pathologic immune cells." @default.
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- W3081938172 date "2020-09-02" @default.
- W3081938172 modified "2023-09-23" @default.
- W3081938172 title "Tet2 Controls β cells Responses to Inflammation in Type 1 Diabetes" @default.
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- W3081938172 doi "https://doi.org/10.1101/2020.09.01.278028" @default.
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