Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082008652> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W3082008652 endingPage "1008" @default.
- W3082008652 startingPage "1008" @default.
- W3082008652 abstract "Abstract We have previously developed a murine model of the hematopoietic acute radiation syndrome [H-ARS, total body irradiated (TBI)] and delayed effects of acute radiation exposure (DEARE) for efficacy testing of potential medical countermeasures (MCM) against these two syndromes. Using this model, we have previously reported that prophylactic use of 16,16 dimethyl-prostaglandin E2 (dmPGE2), a long-acting formulation of PGE, before irradiation significantly increases 30-day survival rate. The current study investigated the effects of the prophylactic use of dmPGE2 with or without therapeutic use of dmPGE2 in survivors on long-term thymus recovery in H-ARS survivors at 6 and 12-months post-LD70/30 (872cGy, 137Cs, 95.2±4.8 cGy/min). Mice were irradiated at 12 weeks of age and then injected subcutaneously with dmPGE2 (1 dose of 35 ug dmPGE2/mouse) or vehicle (Veh; ethanol/PBS solution) at 30“ or -1hr pre-TBI. Survivors were injected monthly with dmPGE2 or Veh and then analyzed for evidence of thymic reconstitution at 6 and 12 months.post-TBI. The three test groups were: prophylactic dmPGE2 + monthly dmPGE2 (PP), prophylactic dmPGE2 + monthly Veh (PV), and prophylactic Veh + monthly Veh (VV), n = 3-6 mice/group. Thymus weight and cellularity of mice in the dmPGE groups, PV and PP, were increased compared to Veh both at 6-months and 12-months post-TBI (p Disclosures No relevant conflicts of interest to declare." @default.
- W3082008652 created "2020-09-08" @default.
- W3082008652 creator A5000560911 @default.
- W3082008652 creator A5011433981 @default.
- W3082008652 creator A5013836476 @default.
- W3082008652 creator A5016858421 @default.
- W3082008652 creator A5024612607 @default.
- W3082008652 date "2017-12-07" @default.
- W3082008652 modified "2023-10-01" @default.
- W3082008652 title "Prostaglandin E2 Promotes Recovery of Thymus in Survivors of the Hematopoietic Acute Radiation Syndrome (H-ARS)" @default.
- W3082008652 doi "https://doi.org/10.1182/blood.v130.suppl_1.1008.1008" @default.
- W3082008652 hasPublicationYear "2017" @default.
- W3082008652 type Work @default.
- W3082008652 sameAs 3082008652 @default.
- W3082008652 citedByCount "0" @default.
- W3082008652 crossrefType "journal-article" @default.
- W3082008652 hasAuthorship W3082008652A5000560911 @default.
- W3082008652 hasAuthorship W3082008652A5011433981 @default.
- W3082008652 hasAuthorship W3082008652A5013836476 @default.
- W3082008652 hasAuthorship W3082008652A5016858421 @default.
- W3082008652 hasAuthorship W3082008652A5024612607 @default.
- W3082008652 hasConcept C109159458 @default.
- W3082008652 hasConcept C126322002 @default.
- W3082008652 hasConcept C2777956040 @default.
- W3082008652 hasConcept C2780664492 @default.
- W3082008652 hasConcept C28328180 @default.
- W3082008652 hasConcept C2908890008 @default.
- W3082008652 hasConcept C54355233 @default.
- W3082008652 hasConcept C71924100 @default.
- W3082008652 hasConcept C86803240 @default.
- W3082008652 hasConceptScore W3082008652C109159458 @default.
- W3082008652 hasConceptScore W3082008652C126322002 @default.
- W3082008652 hasConceptScore W3082008652C2777956040 @default.
- W3082008652 hasConceptScore W3082008652C2780664492 @default.
- W3082008652 hasConceptScore W3082008652C28328180 @default.
- W3082008652 hasConceptScore W3082008652C2908890008 @default.
- W3082008652 hasConceptScore W3082008652C54355233 @default.
- W3082008652 hasConceptScore W3082008652C71924100 @default.
- W3082008652 hasConceptScore W3082008652C86803240 @default.
- W3082008652 hasLocation W30820086521 @default.
- W3082008652 hasOpenAccess W3082008652 @default.
- W3082008652 hasPrimaryLocation W30820086521 @default.
- W3082008652 hasRelatedWork W1951693378 @default.
- W3082008652 hasRelatedWork W2002397046 @default.
- W3082008652 hasRelatedWork W2050387191 @default.
- W3082008652 hasRelatedWork W2084217840 @default.
- W3082008652 hasRelatedWork W2287087682 @default.
- W3082008652 hasRelatedWork W2364058836 @default.
- W3082008652 hasRelatedWork W2377686625 @default.
- W3082008652 hasRelatedWork W2384209390 @default.
- W3082008652 hasRelatedWork W2413680921 @default.
- W3082008652 hasRelatedWork W2419571489 @default.
- W3082008652 hasRelatedWork W2467865376 @default.
- W3082008652 hasRelatedWork W2553778620 @default.
- W3082008652 hasRelatedWork W2558437698 @default.
- W3082008652 hasRelatedWork W2885525565 @default.
- W3082008652 hasRelatedWork W2913853750 @default.
- W3082008652 hasRelatedWork W3002426917 @default.
- W3082008652 hasRelatedWork W3029287980 @default.
- W3082008652 hasRelatedWork W3030365150 @default.
- W3082008652 hasRelatedWork W96428125 @default.
- W3082008652 hasRelatedWork W166843077 @default.
- W3082008652 hasVolume "130" @default.
- W3082008652 isParatext "false" @default.
- W3082008652 isRetracted "false" @default.
- W3082008652 magId "3082008652" @default.
- W3082008652 workType "article" @default.