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• W3082024055 startingPage "12682" @default.
• W3082024055 abstract "A density functional theory study is presented here to offer mechanistic insights and explications of experimentally intriguing observations in the Au(I)-catalyzed cyclization of cyclic and acyclic acetals of alkynylaldehydes that leads to indenone formation. The reactivity of catalytic cycles with and without methoxy migration is clearly defined when the alkyne terminus is phenylated. The reaction mechanism of indenone formation proceeds first with the coordination of Au(I) to alkyne to initiate the reaction with 1,5-H shift as a rate-determining step (RDS), and the fastest 1,5-H shift is achieved when one phenyl ring carries an electron-donating group and the other one is substituted with an electron-withdrawing group. Following the 1,5-H shift, the reaction undergoes feasible steps that are cyclization and 1,2-H shift before elimination to persist the iterative cycle, but the reactivity of both steps is highly affected by the existence of the phenyl group on the alkyne terminus. The unreactivity of the alkyne terminus not bearing a phenyl ring is because the cyclization is thermodynamically disfavorable, subsequently deactivating the 1,2-H shift kinetically and thermodynamically. The absence of a tether in the acetal unit considerably outpaces any 1,5-H shift and instead activates 1,5-methoxy migration, giving methoxy-migrated indenone, with the 1,2-OMe shift being an RDS." @default.
• W3082024055 created "2020-09-08" @default.
• W3082024055 creator A5003039837 @default.
• W3082024055 creator A5088487590 @default.
• W3082024055 date "2020-08-31" @default.
• W3082024055 modified "2023-10-18" @default.
• W3082024055 title "Revealing the Mechanism and Origin of Reactivity of Au(I)-Catalyzed Functionalized Indenone Formation of Cyclic and Acyclic Acetals of Alkynylaldehydes" @default.
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• W3082024055 doi "https://doi.org/10.1021/acs.joc.0c01845" @default.
• W3082024055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32865412" @default.
• W3082024055 hasPublicationYear "2020" @default.
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