Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082024563> ?p ?o ?g. }
- W3082024563 abstract "SARS-CoV-2 is a positive sense RNA coronavirus that constitutes a new threat for the global community and economy. While vaccines against SARS-CoV-2 are being developed, the mechanisms through which this virus takes control of an infected cell to replicate remains poorly understood. Upon infection, viruses completely rely on host cell molecular machinery to survive and replicate. To escape from the immune response and proliferate, viruses strategically modulate cellular metabolism and alter subcellular organelle architecture and functions. One way they do this is by modulating the structure and function of mitochondria, a critical cellular metabolic hub but also a key platform for the regulation of cellular immunity. This versatile nature of mitochondria defends host cells from viruses through several mechanisms including cellular apoptosis, ROS signaling, MAVS activation and mitochondrial DNA-dependent immune activation. These events are regulated by mitochondrial dynamics, a process by which mitochondria alter their structure (including their length and connectivity) in response to stress or other cues. It is therefore not surprising that viruses, including coronaviruses hijack these processes for their survival. In this review, we highlight how positive sense RNA viruses modulate mitochondrial dynamics and metabolism to evade mitochondrial mediated immune response in order to proliferate." @default.
- W3082024563 created "2020-09-08" @default.
- W3082024563 creator A5013862357 @default.
- W3082024563 creator A5053732459 @default.
- W3082024563 creator A5056928038 @default.
- W3082024563 creator A5076635864 @default.
- W3082024563 date "2020-08-28" @default.
- W3082024563 modified "2023-10-16" @default.
- W3082024563 title "Mitochondria Targeted Viral Replication and Survival Strategies—Prospective on SARS-CoV-2" @default.
- W3082024563 cites W1790919501 @default.
- W3082024563 cites W1964468772 @default.
- W3082024563 cites W1968301448 @default.
- W3082024563 cites W1968468219 @default.
- W3082024563 cites W1972381161 @default.
- W3082024563 cites W1975521267 @default.
- W3082024563 cites W1976648979 @default.
- W3082024563 cites W1978424248 @default.
- W3082024563 cites W1978737642 @default.
- W3082024563 cites W1981049765 @default.
- W3082024563 cites W1989061093 @default.
- W3082024563 cites W1998332163 @default.
- W3082024563 cites W2013669585 @default.
- W3082024563 cites W2019799886 @default.
- W3082024563 cites W2028092741 @default.
- W3082024563 cites W2031277784 @default.
- W3082024563 cites W2031837751 @default.
- W3082024563 cites W2034647006 @default.
- W3082024563 cites W2034657763 @default.
- W3082024563 cites W2040462912 @default.
- W3082024563 cites W2042643208 @default.
- W3082024563 cites W2045000874 @default.
- W3082024563 cites W2046984465 @default.
- W3082024563 cites W2050937759 @default.
- W3082024563 cites W2054115583 @default.
- W3082024563 cites W2054193843 @default.
- W3082024563 cites W2055567196 @default.
- W3082024563 cites W2057319454 @default.
- W3082024563 cites W2060989636 @default.
- W3082024563 cites W2065692670 @default.
- W3082024563 cites W2072274257 @default.
- W3082024563 cites W2082540550 @default.
- W3082024563 cites W2082933842 @default.
- W3082024563 cites W2084281888 @default.
- W3082024563 cites W2087661745 @default.
- W3082024563 cites W2093921916 @default.
- W3082024563 cites W2102610618 @default.
- W3082024563 cites W2107513655 @default.
- W3082024563 cites W2111058723 @default.
- W3082024563 cites W2113689677 @default.
- W3082024563 cites W2122511992 @default.
- W3082024563 cites W2126133274 @default.
- W3082024563 cites W2135130417 @default.
- W3082024563 cites W2139636031 @default.
- W3082024563 cites W2144429812 @default.
- W3082024563 cites W2151901780 @default.
- W3082024563 cites W2151928697 @default.
- W3082024563 cites W2152793164 @default.
- W3082024563 cites W2164886443 @default.
- W3082024563 cites W2165404282 @default.
- W3082024563 cites W2171435588 @default.
- W3082024563 cites W2269880005 @default.
- W3082024563 cites W2289342211 @default.
- W3082024563 cites W2330407522 @default.
- W3082024563 cites W2507412157 @default.
- W3082024563 cites W2510523315 @default.
- W3082024563 cites W2530253449 @default.
- W3082024563 cites W2547513157 @default.
- W3082024563 cites W2577945573 @default.
- W3082024563 cites W2580573179 @default.
- W3082024563 cites W2624386828 @default.
- W3082024563 cites W2735590725 @default.
- W3082024563 cites W2783922851 @default.
- W3082024563 cites W2793821504 @default.
- W3082024563 cites W2809281987 @default.
- W3082024563 cites W2888783945 @default.
- W3082024563 cites W2892489769 @default.
- W3082024563 cites W2904701167 @default.
- W3082024563 cites W2910213650 @default.
- W3082024563 cites W2912141593 @default.
- W3082024563 cites W2913441877 @default.
- W3082024563 cites W2913914680 @default.
- W3082024563 cites W2942166600 @default.
- W3082024563 cites W2971840884 @default.
- W3082024563 cites W2983495132 @default.
- W3082024563 cites W2989715356 @default.
- W3082024563 cites W2995721821 @default.
- W3082024563 cites W3003464757 @default.
- W3082024563 cites W3004318991 @default.
- W3082024563 cites W3005619147 @default.
- W3082024563 cites W3006316914 @default.
- W3082024563 cites W3007815320 @default.
- W3082024563 cites W3008000594 @default.
- W3082024563 cites W3008874180 @default.
- W3082024563 cites W3012709102 @default.
- W3082024563 cites W3013395653 @default.
- W3082024563 cites W3022285953 @default.
- W3082024563 doi "https://doi.org/10.3389/fphar.2020.578599" @default.
- W3082024563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7485471" @default.
- W3082024563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32982760" @default.
- W3082024563 hasPublicationYear "2020" @default.