FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082028596> ?p ?o ?g. }

• W3082028596 endingPage "2454" @default.
• W3082028596 startingPage "2454" @default.
• W3082028596 abstract "Malignant Pleural Mesothelioma (MPM) is a heterogeneous disease. Morphologically, three different phenotypes are distinguishable: epithelioid (e-), sarcomatoid (s-) and biphasic (biph-) MPM, the latest, being a mixture of e- and s-MPM cells. Being an intermediate entity, management of biph-MPM, remains debatable and controversial, with different guidelines recommending distinct approaches. Identification of biph-MPM associated genetic alterations, through deep sequencing analysis, may provide useful tools to understand these lesions. A retrospective cohort of 69 surgically resected MPMs, 39 biph-MPMs (56.5%) and 30 e-MPMs (43.5%) was selected. A separate set of 16 biph-MPM was used as validation set. Deep sequencing analysis on an MPM-specific custom panel (MPM_geneset) comprising 1041 amplicons spanning 34 genes was performed. A total of 588 variants and 5309 mutational events were detected. In total, 91.3% of MPMs showed at least one mutation and 76.8% showed co-occurrence of more than one alteration. Mutations in MXRA5 (p = 0.05) and NOD2 (p = 0.018) were significantly associated with biph-MPM both in the training and validation cohort and correlated with the extent of the sarcomatoid component. Mutations in NOD2 and XRCC6 correlated with patients’ survival. We demonstrated that biph-MPM are associated with a specific mutation set, and that genetic analysis at diagnosis may improve patients’ risk stratification." @default.
• W3082028596 created "2020-09-08" @default.
• W3082028596 creator A5004557133 @default.
• W3082028596 creator A5014045886 @default.
• W3082028596 creator A5018301656 @default.
• W3082028596 creator A5019446584 @default.
• W3082028596 creator A5042559824 @default.
• W3082028596 creator A5043896307 @default.
• W3082028596 creator A5060916338 @default.
• W3082028596 creator A5063098368 @default.
• W3082028596 creator A5071565230 @default.
• W3082028596 creator A5085105094 @default.
• W3082028596 date "2020-08-29" @default.
• W3082028596 modified "2023-10-17" @default.
• W3082028596 title "Deep Sequencing Analysis Identified a Specific Subset of Mutations Distinctive of Biphasic Malignant Pleural Mesothelioma" @default.
• W3082028596 cites W1780578436 @default.
• W3082028596 cites W1953677527 @default.
• W3082028596 cites W1966301772 @default.
• W3082028596 cites W1974249295 @default.
• W3082028596 cites W1975657424 @default.
• W3082028596 cites W1976644844 @default.
• W3082028596 cites W1977849264 @default.
• W3082028596 cites W1985213644 @default.
• W3082028596 cites W1997241984 @default.
• W3082028596 cites W2001166572 @default.
• W3082028596 cites W2011554254 @default.
• W3082028596 cites W2026986828 @default.
• W3082028596 cites W2034042626 @default.
• W3082028596 cites W2034914142 @default.
• W3082028596 cites W2040333874 @default.
• W3082028596 cites W2045912662 @default.
• W3082028596 cites W2056106944 @default.
• W3082028596 cites W2084180192 @default.
• W3082028596 cites W2118880233 @default.
• W3082028596 cites W2120475018 @default.
• W3082028596 cites W2127094227 @default.
• W3082028596 cites W2147695423 @default.
• W3082028596 cites W2270944159 @default.
• W3082028596 cites W2287191467 @default.
• W3082028596 cites W2291531085 @default.
• W3082028596 cites W2337752842 @default.
• W3082028596 cites W2397028098 @default.
• W3082028596 cites W2416288303 @default.
• W3082028596 cites W2513003030 @default.
• W3082028596 cites W2595525832 @default.
• W3082028596 cites W2597872842 @default.
• W3082028596 cites W2739145658 @default.
• W3082028596 cites W2774771920 @default.
• W3082028596 cites W2798183676 @default.
• W3082028596 cites W2802627246 @default.
• W3082028596 cites W2884835461 @default.
• W3082028596 cites W2897299514 @default.
• W3082028596 cites W2924341172 @default.
• W3082028596 cites W2944582987 @default.
• W3082028596 cites W2972318540 @default.
• W3082028596 doi "https://doi.org/10.3390/cancers12092454" @default.
• W3082028596 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7563974" @default.
• W3082028596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32872534" @default.
• W3082028596 hasPublicationYear "2020" @default.
• W3082028596 type Work @default.
• W3082028596 sameAs 3082028596 @default.
• W3082028596 citedByCount "6" @default.
• W3082028596 countsByYear W30820285962021 @default.
• W3082028596 countsByYear W30820285962023 @default.
• W3082028596 crossrefType "journal-article" @default.
• W3082028596 hasAuthorship W3082028596A5004557133 @default.
• W3082028596 hasAuthorship W3082028596A5014045886 @default.
• W3082028596 hasAuthorship W3082028596A5018301656 @default.
• W3082028596 hasAuthorship W3082028596A5019446584 @default.
• W3082028596 hasAuthorship W3082028596A5042559824 @default.
• W3082028596 hasAuthorship W3082028596A5043896307 @default.
• W3082028596 hasAuthorship W3082028596A5060916338 @default.
• W3082028596 hasAuthorship W3082028596A5063098368 @default.
• W3082028596 hasAuthorship W3082028596A5071565230 @default.
• W3082028596 hasAuthorship W3082028596A5085105094 @default.
• W3082028596 hasBestOaLocation W30820285961 @default.
• W3082028596 hasConcept C104317684 @default.
• W3082028596 hasConcept C126322002 @default.
• W3082028596 hasConcept C127716648 @default.
• W3082028596 hasConcept C142724271 @default.
• W3082028596 hasConcept C143998085 @default.
• W3082028596 hasConcept C163565370 @default.
• W3082028596 hasConcept C2777407522 @default.
• W3082028596 hasConcept C2993206177 @default.
• W3082028596 hasConcept C42062724 @default.
• W3082028596 hasConcept C49105822 @default.
• W3082028596 hasConcept C501734568 @default.
• W3082028596 hasConcept C502942594 @default.
• W3082028596 hasConcept C54355233 @default.
• W3082028596 hasConcept C71924100 @default.
• W3082028596 hasConcept C8185291 @default.
• W3082028596 hasConcept C86803240 @default.
• W3082028596 hasConceptScore W3082028596C104317684 @default.
• W3082028596 hasConceptScore W3082028596C126322002 @default.
• W3082028596 hasConceptScore W3082028596C127716648 @default.
• W3082028596 hasConceptScore W3082028596C142724271 @default.
• W3082028596 hasConceptScore W3082028596C143998085 @default.
• W3082028596 hasConceptScore W3082028596C163565370 @default.

• next