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- W3082062689 abstract "Doxorubicin (Dox) is a first-line treatment for triple negative breast cancer (TNBC), which lacks the molecular targets for hormone or growth factor therapy. Although highly effective as a chemotherapeutic agent, Dox induces severe side effects including cardiotoxicity that can cause patients to stop treatment early and impact the long-term health of patients in remission. Reactive oxygen species (ROS) are the predominant contributing factor to Dox-induced cardiotoxicity. Here, we sought to use the antioxidant vitamin D to provide a cardioprotective environment to prevent or reduce cardiotoxicity in a mouse model of TNBC. Supplementation with vitamin D (10,000 IU/kg) in chow for two weeks significantly increased the active vitamin D metabolite (25(OH)VD3) in plasma from 61.2 ± 4.5 nM (Mean ± SEM) to 85.0 ± 6.3 nM (P Citation Format: Kevin J. Lee, Griffin Wright, Leigh Ann Wiggins, Michele Schuler, Natalie R. Gassman. Vitamin D supplementation to improve doxorubicin-induced cardiotoxicity in triple negative breast cancers [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3464." @default.
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- W3082062689 date "2020-08-13" @default.
- W3082062689 modified "2023-10-17" @default.
- W3082062689 title "Abstract 3464: Vitamin D supplementation to improve doxorubicin-induced cardiotoxicity in triple negative breast cancers" @default.
- W3082062689 doi "https://doi.org/10.1158/1538-7445.am2020-3464" @default.
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