FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082079594> ?p ?o ?g. }

• W3082079594 endingPage "6372" @default.
• W3082079594 startingPage "6372" @default.
• W3082079594 abstract "Human Respiratory Syncytial Virus and Human Rhinovirus are the most frequent cause of respiratory tract infections in infants and children and are major triggers of acute viral bronchiolitis, wheezing and asthma exacerbations. Here, we will discuss the application of the powerful tools of systems biology to decode the molecular mechanisms that determine risk for infection and subsequent asthma. An important conceptual advance is the understanding that the innate immune system is governed by a Bow-tie architecture, where diverse input signals converge onto a few core pathways (e.g., IRF7), which in turn generate diverse outputs that orchestrate effector and regulatory functions. Molecular profiling studies in children with severe exacerbations of asthma/wheeze have identified two major immunological phenotypes. The IRF7hi phenotype is characterised by robust upregulation of antiviral response networks, and the IRF7lo phenotype is characterised by upregulation of markers of TGFβ signalling and type 2 inflammation. Similar phenotypes have been identified in infants and children with severe viral bronchiolitis. Notably, genome-wide association studies supported by experimental validation have identified key pathways that increase susceptibility to HRV infection (ORMDL3 and CHDR3) and modulate TGFβ signalling (GSDMB, TGFBR1, and SMAD3). Moreover, functional deficiencies in the activation of type I and III interferon responses are already evident at birth in children at risk of developing febrile lower respiratory tract infections and persistent asthma/wheeze, suggesting that the trajectory to asthma begins at birth or in utero. Finally, exposure to microbes and their products reprograms innate immunity and provides protection from the development of allergies and asthma in children, and therefore microbial products are logical candidates for the primary prevention of asthma." @default.
• W3082079594 created "2020-09-08" @default.
• W3082079594 creator A5013178111 @default.
• W3082079594 creator A5026627982 @default.
• W3082079594 date "2020-09-02" @default.
• W3082079594 modified "2023-10-12" @default.
• W3082079594 title "Decoding Susceptibility to Respiratory Viral Infections and Asthma Inception in Children" @default.
• W3082079594 cites W1488537470 @default.
• W3082079594 cites W1566831845 @default.
• W3082079594 cites W1969602971 @default.
• W3082079594 cites W1977853360 @default.
• W3082079594 cites W1980812572 @default.
• W3082079594 cites W1984883254 @default.
• W3082079594 cites W1992974787 @default.
• W3082079594 cites W1998712640 @default.
• W3082079594 cites W2007608885 @default.
• W3082079594 cites W2008599922 @default.
• W3082079594 cites W2011678998 @default.
• W3082079594 cites W2012568595 @default.
• W3082079594 cites W2020800229 @default.
• W3082079594 cites W2035573793 @default.
• W3082079594 cites W2039591446 @default.
• W3082079594 cites W2042908825 @default.
• W3082079594 cites W2048769932 @default.
• W3082079594 cites W2050158252 @default.
• W3082079594 cites W2051954214 @default.
• W3082079594 cites W2054045630 @default.
• W3082079594 cites W2065445260 @default.
• W3082079594 cites W2068923658 @default.
• W3082079594 cites W2072063345 @default.
• W3082079594 cites W2080554049 @default.
• W3082079594 cites W2089198104 @default.
• W3082079594 cites W2089627898 @default.
• W3082079594 cites W2096683863 @default.
• W3082079594 cites W2100589529 @default.
• W3082079594 cites W2103681608 @default.
• W3082079594 cites W2127825607 @default.
• W3082079594 cites W2135670417 @default.
• W3082079594 cites W2135837680 @default.
• W3082079594 cites W2146484207 @default.
• W3082079594 cites W2162088497 @default.
• W3082079594 cites W2163393883 @default.
• W3082079594 cites W2163738297 @default.
• W3082079594 cites W2164549228 @default.
• W3082079594 cites W2165247488 @default.
• W3082079594 cites W2166745068 @default.
• W3082079594 cites W2171580484 @default.
• W3082079594 cites W2174861227 @default.
• W3082079594 cites W2180092497 @default.
• W3082079594 cites W2239108612 @default.
• W3082079594 cites W2257479343 @default.
• W3082079594 cites W2263690784 @default.
• W3082079594 cites W2268091062 @default.
• W3082079594 cites W2276765849 @default.
• W3082079594 cites W2337928173 @default.
• W3082079594 cites W2346069395 @default.
• W3082079594 cites W2467111379 @default.
• W3082079594 cites W2484915396 @default.
• W3082079594 cites W2503207524 @default.
• W3082079594 cites W2535680382 @default.
• W3082079594 cites W2542623541 @default.
• W3082079594 cites W2550596635 @default.
• W3082079594 cites W2563730257 @default.
• W3082079594 cites W2586644068 @default.
• W3082079594 cites W2593848357 @default.
• W3082079594 cites W2605810679 @default.
• W3082079594 cites W2611138580 @default.
• W3082079594 cites W2612511627 @default.
• W3082079594 cites W2612664452 @default.
• W3082079594 cites W2613240323 @default.
• W3082079594 cites W2614636468 @default.
• W3082079594 cites W2621743257 @default.
• W3082079594 cites W2626606138 @default.
• W3082079594 cites W2724725767 @default.
• W3082079594 cites W2729102371 @default.
• W3082079594 cites W2735796242 @default.
• W3082079594 cites W2760886426 @default.
• W3082079594 cites W2765256236 @default.
• W3082079594 cites W2766959028 @default.
• W3082079594 cites W2768322624 @default.
• W3082079594 cites W2769999515 @default.
• W3082079594 cites W2780232486 @default.
• W3082079594 cites W2781086241 @default.
• W3082079594 cites W2782174691 @default.
• W3082079594 cites W2786769016 @default.
• W3082079594 cites W2788404815 @default.
• W3082079594 cites W2789414316 @default.
• W3082079594 cites W2789891333 @default.
• W3082079594 cites W2851656101 @default.
• W3082079594 cites W2885499809 @default.
• W3082079594 cites W2887886950 @default.
• W3082079594 cites W2888423166 @default.
• W3082079594 cites W2889504223 @default.
• W3082079594 cites W2889628524 @default.
• W3082079594 cites W2889794943 @default.
• W3082079594 cites W2890697585 @default.
• W3082079594 cites W2891898023 @default.
• W3082079594 cites W2897044637 @default.

• next