Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082110499> ?p ?o ?g. }
- W3082110499 endingPage "5162" @default.
- W3082110499 startingPage "5148" @default.
- W3082110499 abstract "The vasomotor role of K2P potassium channels during early postnatal development has never been investigated. We tested the hypothesis that TASK-1 channel (K2P family member) contribution to arterial vascular tone and BP is higher in the early postnatal period than in adulthood.We studied 10- to 15-day-old (young) and 2- to 3-month-old (adult) male rats performing digital PCR (dPCR) (using endothelium-intact saphenous arteries), isometric myography, sharp microelectrode technique, quantitative PCR (qPCR) and Western blotting (using endothelium-denuded saphenous arteries), and arterial pressure measurements under urethane anaesthesia.We found mRNA of Kcnk1-Kcnk7, Kcnk12, and Kcnk13 genes to be expressed in rat saphenous artery, and Kcnk3 (TASK-1) and Kcnk6 (TWIK-2) were most abundant in both age groups. The TASK-1 channel blocker AVE1231 (1 μmol·L-1 ) prominently depolarized arterial smooth muscle and increased basal tone level and contractile responses to methoxamine of arteries from young rats but had almost no effect in adult rats. The level of TASK-1 mRNA and protein expression was higher in arteries from young compared with adult rats. Importantly, intravenous administration of AVE1231 (4 mg·kg-1 ) had no effect on mean arterial pressure in adult rats but prominently raised it in young rats.We showed that TASK-1 channels are important for negative feedback regulation of vasocontraction in young but not adult rats. The influence of TASK-1 channels most likely contributes to low BP level at perinatal age." @default.
- W3082110499 created "2020-09-08" @default.
- W3082110499 creator A5002685729 @default.
- W3082110499 creator A5021073464 @default.
- W3082110499 creator A5025924989 @default.
- W3082110499 creator A5037077016 @default.
- W3082110499 creator A5041782412 @default.
- W3082110499 creator A5079986408 @default.
- W3082110499 creator A5086546388 @default.
- W3082110499 date "2020-09-24" @default.
- W3082110499 modified "2023-10-18" @default.
- W3082110499 title "TASK‐1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1‐ to 2‐week‐old but not adult rats" @default.
- W3082110499 cites W1499202962 @default.
- W3082110499 cites W1541419413 @default.
- W3082110499 cites W1966143879 @default.
- W3082110499 cites W1968393474 @default.
- W3082110499 cites W1970445852 @default.
- W3082110499 cites W1983494432 @default.
- W3082110499 cites W1985417036 @default.
- W3082110499 cites W1990898009 @default.
- W3082110499 cites W1991927910 @default.
- W3082110499 cites W1993074454 @default.
- W3082110499 cites W2013711923 @default.
- W3082110499 cites W2019243524 @default.
- W3082110499 cites W2030922163 @default.
- W3082110499 cites W2040179661 @default.
- W3082110499 cites W2049613245 @default.
- W3082110499 cites W2049732841 @default.
- W3082110499 cites W2051079514 @default.
- W3082110499 cites W2056527946 @default.
- W3082110499 cites W2070517934 @default.
- W3082110499 cites W2079742647 @default.
- W3082110499 cites W2081680109 @default.
- W3082110499 cites W2082201595 @default.
- W3082110499 cites W2095731799 @default.
- W3082110499 cites W2100642038 @default.
- W3082110499 cites W2106522615 @default.
- W3082110499 cites W2108810476 @default.
- W3082110499 cites W2121836743 @default.
- W3082110499 cites W2125834510 @default.
- W3082110499 cites W2130111691 @default.
- W3082110499 cites W2136309995 @default.
- W3082110499 cites W2136347991 @default.
- W3082110499 cites W2139469425 @default.
- W3082110499 cites W2155067282 @default.
- W3082110499 cites W2155881793 @default.
- W3082110499 cites W2282364919 @default.
- W3082110499 cites W2286230727 @default.
- W3082110499 cites W2290466312 @default.
- W3082110499 cites W2494533873 @default.
- W3082110499 cites W2596973760 @default.
- W3082110499 cites W2761478100 @default.
- W3082110499 cites W2786163341 @default.
- W3082110499 cites W2791419854 @default.
- W3082110499 cites W2792530460 @default.
- W3082110499 cites W2888578323 @default.
- W3082110499 cites W2923711337 @default.
- W3082110499 cites W2964522868 @default.
- W3082110499 cites W2984194970 @default.
- W3082110499 cites W2985450688 @default.
- W3082110499 cites W3042519295 @default.
- W3082110499 cites W3047879827 @default.
- W3082110499 cites W3082110499 @default.
- W3082110499 cites W4236357753 @default.
- W3082110499 doi "https://doi.org/10.1111/bph.15249" @default.
- W3082110499 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7589011" @default.
- W3082110499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32860629" @default.
- W3082110499 hasPublicationYear "2020" @default.
- W3082110499 type Work @default.
- W3082110499 sameAs 3082110499 @default.
- W3082110499 citedByCount "9" @default.
- W3082110499 countsByYear W30821104992020 @default.
- W3082110499 countsByYear W30821104992021 @default.
- W3082110499 countsByYear W30821104992022 @default.
- W3082110499 countsByYear W30821104992023 @default.
- W3082110499 crossrefType "journal-article" @default.
- W3082110499 hasAuthorship W3082110499A5002685729 @default.
- W3082110499 hasAuthorship W3082110499A5021073464 @default.
- W3082110499 hasAuthorship W3082110499A5025924989 @default.
- W3082110499 hasAuthorship W3082110499A5037077016 @default.
- W3082110499 hasAuthorship W3082110499A5041782412 @default.
- W3082110499 hasAuthorship W3082110499A5079986408 @default.
- W3082110499 hasAuthorship W3082110499A5086546388 @default.
- W3082110499 hasBestOaLocation W30821104991 @default.
- W3082110499 hasConcept C103486182 @default.
- W3082110499 hasConcept C120770815 @default.
- W3082110499 hasConcept C126322002 @default.
- W3082110499 hasConcept C134018914 @default.
- W3082110499 hasConcept C170493617 @default.
- W3082110499 hasConcept C1918360 @default.
- W3082110499 hasConcept C2776214587 @default.
- W3082110499 hasConcept C2778938600 @default.
- W3082110499 hasConcept C2779961880 @default.
- W3082110499 hasConcept C2780745239 @default.
- W3082110499 hasConcept C71924100 @default.
- W3082110499 hasConcept C83743174 @default.
- W3082110499 hasConcept C84393581 @default.
- W3082110499 hasConceptScore W3082110499C103486182 @default.