Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082118226> ?p ?o ?g. }
- W3082118226 abstract "Abstract Lung adenocarcinoma, the most prevalent lung cancer subtype, is characterized by its high propensity to metastasize. Despite the importance of metastasis in lung cancer mortality, its underlying cellular and molecular mechanisms remain largely elusive. Here, we identified miR-200 miRNAs as potent suppressors for lung adenocarcinoma metastasis. miR-200 expression is specifically repressed in mouse metastatic lung adenocarcinomas, and miR-200 decrease strongly correlates with poor patient survival. Consistently, deletion of mir-200c/141 in the Kras LSL-G12D/+ ; Trp53 flox/flox lung adenocarcinoma mouse model significantly promoted metastasis, generating a desmoplastic tumor stroma highly reminiscent of metastatic human lung cancer. miR-200 deficiency in lung cancer cells promotes the proliferation and activation of adjacent cancer-associated fibroblasts (CAFs), which in turn elevates the metastatic potential of cancer cells. miR-200 regulates the functional interaction between cancer cells and CAFs, at least in part, by targeting Notch ligand Jagged1 and Jagged2 in cancer cells and inducing Notch activation in adjacent CAFs. Hence, the interaction between cancer cells and CAFs constitutes an essential mechanism to promote metastatic potential." @default.
- W3082118226 created "2020-09-08" @default.
- W3082118226 creator A5008019202 @default.
- W3082118226 creator A5012375412 @default.
- W3082118226 creator A5020493997 @default.
- W3082118226 creator A5029202750 @default.
- W3082118226 creator A5036222578 @default.
- W3082118226 creator A5039780162 @default.
- W3082118226 creator A5051974782 @default.
- W3082118226 creator A5053239891 @default.
- W3082118226 creator A5053670766 @default.
- W3082118226 creator A5062358716 @default.
- W3082118226 creator A5067622842 @default.
- W3082118226 creator A5072295661 @default.
- W3082118226 creator A5079413885 @default.
- W3082118226 creator A5080322984 @default.
- W3082118226 creator A5081064913 @default.
- W3082118226 creator A5083902642 @default.
- W3082118226 creator A5087532232 @default.
- W3082118226 date "2020-09-03" @default.
- W3082118226 modified "2023-10-16" @default.
- W3082118226 title "miR-200 deficiency promotes lung cancer metastasis by activating cancer-associated fibroblasts" @default.
- W3082118226 cites W1581259003 @default.
- W3082118226 cites W1918975836 @default.
- W3082118226 cites W1963549191 @default.
- W3082118226 cites W1967801503 @default.
- W3082118226 cites W1975238117 @default.
- W3082118226 cites W1980039397 @default.
- W3082118226 cites W1983575915 @default.
- W3082118226 cites W1983991097 @default.
- W3082118226 cites W1994772304 @default.
- W3082118226 cites W1997801717 @default.
- W3082118226 cites W2012124753 @default.
- W3082118226 cites W2027146979 @default.
- W3082118226 cites W2032019019 @default.
- W3082118226 cites W2033278321 @default.
- W3082118226 cites W2037023229 @default.
- W3082118226 cites W2037647570 @default.
- W3082118226 cites W2039685773 @default.
- W3082118226 cites W2042736191 @default.
- W3082118226 cites W2045295282 @default.
- W3082118226 cites W2046284157 @default.
- W3082118226 cites W2055624262 @default.
- W3082118226 cites W2058734213 @default.
- W3082118226 cites W2062809449 @default.
- W3082118226 cites W2071466888 @default.
- W3082118226 cites W2079347556 @default.
- W3082118226 cites W2089956125 @default.
- W3082118226 cites W2099386585 @default.
- W3082118226 cites W2101037339 @default.
- W3082118226 cites W2102059693 @default.
- W3082118226 cites W2104010513 @default.
- W3082118226 cites W2119213109 @default.
- W3082118226 cites W2123453785 @default.
- W3082118226 cites W2123584388 @default.
- W3082118226 cites W2124803006 @default.
- W3082118226 cites W2125120607 @default.
- W3082118226 cites W2127002994 @default.
- W3082118226 cites W2133627237 @default.
- W3082118226 cites W2134629862 @default.
- W3082118226 cites W2141815918 @default.
- W3082118226 cites W2145990138 @default.
- W3082118226 cites W2146040216 @default.
- W3082118226 cites W2152841886 @default.
- W3082118226 cites W2154861644 @default.
- W3082118226 cites W2159793493 @default.
- W3082118226 cites W2160127145 @default.
- W3082118226 cites W2171972690 @default.
- W3082118226 cites W2184867100 @default.
- W3082118226 cites W2341044585 @default.
- W3082118226 cites W2347175105 @default.
- W3082118226 cites W2461903592 @default.
- W3082118226 cites W2465425712 @default.
- W3082118226 cites W2487549822 @default.
- W3082118226 cites W2593037083 @default.
- W3082118226 cites W2612504410 @default.
- W3082118226 cites W2751023845 @default.
- W3082118226 cites W2786421413 @default.
- W3082118226 cites W2800801906 @default.
- W3082118226 cites W2904211489 @default.
- W3082118226 cites W2920295895 @default.
- W3082118226 cites W3004765765 @default.
- W3082118226 doi "https://doi.org/10.1101/2020.09.02.276550" @default.
- W3082118226 hasPublicationYear "2020" @default.
- W3082118226 type Work @default.
- W3082118226 sameAs 3082118226 @default.
- W3082118226 citedByCount "2" @default.
- W3082118226 countsByYear W30821182262021 @default.
- W3082118226 countsByYear W30821182262022 @default.
- W3082118226 crossrefType "posted-content" @default.
- W3082118226 hasAuthorship W3082118226A5008019202 @default.
- W3082118226 hasAuthorship W3082118226A5012375412 @default.
- W3082118226 hasAuthorship W3082118226A5020493997 @default.
- W3082118226 hasAuthorship W3082118226A5029202750 @default.
- W3082118226 hasAuthorship W3082118226A5036222578 @default.
- W3082118226 hasAuthorship W3082118226A5039780162 @default.
- W3082118226 hasAuthorship W3082118226A5051974782 @default.
- W3082118226 hasAuthorship W3082118226A5053239891 @default.
- W3082118226 hasAuthorship W3082118226A5053670766 @default.
- W3082118226 hasAuthorship W3082118226A5062358716 @default.