FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082123597> ?p ?o ?g. }

• W3082123597 endingPage "113352" @default.
• W3082123597 startingPage "113352" @default.
• W3082123597 abstract "Irritable bowel syndrome (IBS) is a chronic, stress-related, functional gastrointestinal disorder characterized by abdominal discomfort and altered bowel habits; the manipulation of the microbiota is emerging as a promising therapeutic option for IBS. Cynanchum thesioides (CT) is an herb of traditional Mongolian medicine that has been employed in treating abdominal pain and diarrhea for hundreds of years. Phytochemical studies of this plant showed the presence of various flavonoids with antibacterial and anti-inflammatory activities. We hypothesized that Cynanchum thesioides manipulates the gut mycobiome and reverses visceral hypersensitivity in IBS rat model. The aims of this study were to prove the in vivo efficacy of Cynanchum thesioides on improving visceral hypersensitivity in IBS rat model and to examine its effect on gut bacterial communities, focusing on the potential interrelationships among microbiota and visceral hypersensitivity. We induced visceral hypersensitivity rat models by maternal separation (MS) of Sprague-Dawley rats, and administered CT water extracts to MS rats for 10 consecutive days. The abdominal withdrawal reflex score and threshold of colorectal distention were employed to assess visceral sensitivity. We then used the Illumina HiSeq platform to analyze bacterial 16S rRNA gene. Treatment with CT improved visceral hypersensitivity in MS rats, and this was accompanied by alterations in the structure and composition of the gut microbiota. The extent of the stability of the gut microbiota was improved after treatment with CT. The genera Pseudomonas, Lachnospiracea_incertae_sedis, and Clostridium XlVa (which were more prevalent in MS rats) were significantly decreased, whereas the abundance of some genera were less prevalent in MS rats—for example, Clostridium IV, Elusimicrobium, Clostridium_sensu_stricto, and Acetatifactor were significantly enriched after treatment with CT. Water-extracted CT was beneficial against visceral hypersensitivity in IBS and favorably affected the structure, composition, and functionality of gut microbiota. CT is therefore a promising agent in therapy of IBS." @default.
• W3082123597 created "2020-09-08" @default.
• W3082123597 creator A5009001630 @default.
• W3082123597 creator A5011811036 @default.
• W3082123597 creator A5034010159 @default.
• W3082123597 creator A5080971094 @default.
• W3082123597 creator A5085170970 @default.
• W3082123597 date "2021-01-01" @default.
• W3082123597 modified "2023-10-10" @default.
• W3082123597 title "Effect of water extracts from Cynanchum thesioides (Freyn) K. Schum. on visceral hypersensitivity and gut microbiota profile in maternally separated rats" @default.
• W3082123597 cites W1974376854 @default.
• W3082123597 cites W1977549443 @default.
• W3082123597 cites W1977804070 @default.
• W3082123597 cites W2027425243 @default.
• W3082123597 cites W2031805480 @default.
• W3082123597 cites W2038460449 @default.
• W3082123597 cites W2040076764 @default.
• W3082123597 cites W2043127479 @default.
• W3082123597 cites W2084536510 @default.
• W3082123597 cites W2107869127 @default.
• W3082123597 cites W2112312875 @default.
• W3082123597 cites W2112848618 @default.
• W3082123597 cites W2113582196 @default.
• W3082123597 cites W2131076700 @default.
• W3082123597 cites W2138706910 @default.
• W3082123597 cites W2164386968 @default.
• W3082123597 cites W2170178906 @default.
• W3082123597 cites W2171025244 @default.
• W3082123597 cites W2190628252 @default.
• W3082123597 cites W2278390975 @default.
• W3082123597 cites W2315148676 @default.
• W3082123597 cites W2344648035 @default.
• W3082123597 cites W2598445433 @default.
• W3082123597 cites W2736538047 @default.
• W3082123597 cites W2794373470 @default.
• W3082123597 cites W2800615720 @default.
• W3082123597 cites W2806695428 @default.
• W3082123597 cites W2896078611 @default.
• W3082123597 cites W2899014430 @default.
• W3082123597 cites W2902815211 @default.
• W3082123597 cites W2912310109 @default.
• W3082123597 cites W2951010457 @default.
• W3082123597 cites W2970943912 @default.
• W3082123597 cites W2999235405 @default.
• W3082123597 doi "https://doi.org/10.1016/j.jep.2020.113352" @default.
• W3082123597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32891821" @default.
• W3082123597 hasPublicationYear "2021" @default.
• W3082123597 type Work @default.
• W3082123597 sameAs 3082123597 @default.
• W3082123597 citedByCount "7" @default.
• W3082123597 countsByYear W30821235972021 @default.
• W3082123597 countsByYear W30821235972022 @default.
• W3082123597 countsByYear W30821235972023 @default.
• W3082123597 crossrefType "journal-article" @default.
• W3082123597 hasAuthorship W3082123597A5009001630 @default.
• W3082123597 hasAuthorship W3082123597A5011811036 @default.
• W3082123597 hasAuthorship W3082123597A5034010159 @default.
• W3082123597 hasAuthorship W3082123597A5080971094 @default.
• W3082123597 hasAuthorship W3082123597A5085170970 @default.
• W3082123597 hasBestOaLocation W30821235971 @default.
• W3082123597 hasConcept C126322002 @default.
• W3082123597 hasConcept C15490471 @default.
• W3082123597 hasConcept C170493617 @default.
• W3082123597 hasConcept C203014093 @default.
• W3082123597 hasConcept C2778271842 @default.
• W3082123597 hasConcept C2779794527 @default.
• W3082123597 hasConcept C2779802037 @default.
• W3082123597 hasConcept C2779824472 @default.
• W3082123597 hasConcept C2780955771 @default.
• W3082123597 hasConcept C2991655182 @default.
• W3082123597 hasConcept C539455810 @default.
• W3082123597 hasConcept C556039675 @default.
• W3082123597 hasConcept C71924100 @default.
• W3082123597 hasConcept C90924648 @default.
• W3082123597 hasConceptScore W3082123597C126322002 @default.
• W3082123597 hasConceptScore W3082123597C15490471 @default.
• W3082123597 hasConceptScore W3082123597C170493617 @default.
• W3082123597 hasConceptScore W3082123597C203014093 @default.
• W3082123597 hasConceptScore W3082123597C2778271842 @default.
• W3082123597 hasConceptScore W3082123597C2779794527 @default.
• W3082123597 hasConceptScore W3082123597C2779802037 @default.
• W3082123597 hasConceptScore W3082123597C2779824472 @default.
• W3082123597 hasConceptScore W3082123597C2780955771 @default.
• W3082123597 hasConceptScore W3082123597C2991655182 @default.
• W3082123597 hasConceptScore W3082123597C539455810 @default.
• W3082123597 hasConceptScore W3082123597C556039675 @default.
• W3082123597 hasConceptScore W3082123597C71924100 @default.
• W3082123597 hasConceptScore W3082123597C90924648 @default.
• W3082123597 hasFunder F4320321001 @default.
• W3082123597 hasFunder F4320328117 @default.
• W3082123597 hasLocation W30821235971 @default.
• W3082123597 hasOpenAccess W3082123597 @default.
• W3082123597 hasPrimaryLocation W30821235971 @default.
• W3082123597 hasRelatedWork W130502936 @default.
• W3082123597 hasRelatedWork W2045572961 @default.
• W3082123597 hasRelatedWork W2147533789 @default.
• W3082123597 hasRelatedWork W2366461646 @default.
• W3082123597 hasRelatedWork W2378639844 @default.

• next