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- W3082136623 endingPage "6377" @default.
- W3082136623 startingPage "6377" @default.
- W3082136623 abstract "The bone is a complex organ that is dependent on a tight regulation between bone formation by osteoblasts (OBs) and bone resorption by osteoclasts (OCs). These processes can be influenced by environmental factors such as ionizing radiation (IR). In cancer therapy, IR is applied in high doses, leading to detrimental effects on bone, whereas radiation therapy with low doses of IR is applied for chronic degenerative and inflammatory diseases, with a positive impact especially on bone homeostasis. Moreover, the effects of IR are of particular interest in space travel, as astronauts suffer from bone loss due to space radiation and microgravity. This review summarizes the current state of knowledge on the effects of IR on bone with a special focus on the influence on OCs and OBs, as these cells are essential in bone remodeling. In addition, the influence of IR on the bone microenvironment is discussed. In summary, the effects of IR on bone and bone remodeling cells strongly depend on the applied radiation dose, as differential results are provided from in vivo as well as in vitro studies with varying doses of IR. Furthermore, the isolated effects of IR on a single cell type are difficult to determine, as the bone cells and bone microenvironment are building a tightly regulated network, influencing on one another. Therefore, future research is necessary in order to elucidate the influence of different bone cells on the overall radiation-induced effects on bone." @default.
- W3082136623 created "2020-09-08" @default.
- W3082136623 creator A5005230207 @default.
- W3082136623 creator A5007087988 @default.
- W3082136623 creator A5027231637 @default.
- W3082136623 creator A5030709807 @default.
- W3082136623 creator A5037761215 @default.
- W3082136623 creator A5090800994 @default.
- W3082136623 date "2020-09-02" @default.
- W3082136623 modified "2023-10-15" @default.
- W3082136623 title "The Influence of Radiation on Bone and Bone Cells—Differential Effects on Osteoclasts and Osteoblasts" @default.
- W3082136623 cites W1484334610 @default.
- W3082136623 cites W1503229621 @default.
- W3082136623 cites W1584193211 @default.
- W3082136623 cites W1673487389 @default.
- W3082136623 cites W1966481454 @default.
- W3082136623 cites W1970795454 @default.
- W3082136623 cites W1973651950 @default.
- W3082136623 cites W1974338398 @default.
- W3082136623 cites W1975354196 @default.
- W3082136623 cites W1979421481 @default.
- W3082136623 cites W1982395713 @default.
- W3082136623 cites W1986311655 @default.
- W3082136623 cites W1988063973 @default.
- W3082136623 cites W1988170766 @default.
- W3082136623 cites W1993069535 @default.
- W3082136623 cites W2000358254 @default.
- W3082136623 cites W2003791420 @default.
- W3082136623 cites W2006328604 @default.
- W3082136623 cites W2007612794 @default.
- W3082136623 cites W2008584099 @default.
- W3082136623 cites W2016390309 @default.
- W3082136623 cites W2017121946 @default.
- W3082136623 cites W2017290871 @default.
- W3082136623 cites W2020571751 @default.
- W3082136623 cites W2022850506 @default.
- W3082136623 cites W2029051823 @default.
- W3082136623 cites W2029367967 @default.
- W3082136623 cites W2032273454 @default.
- W3082136623 cites W2041837231 @default.
- W3082136623 cites W2043575567 @default.
- W3082136623 cites W2045140392 @default.
- W3082136623 cites W2048938597 @default.
- W3082136623 cites W2051424544 @default.
- W3082136623 cites W2055798547 @default.
- W3082136623 cites W2060087149 @default.
- W3082136623 cites W2071324784 @default.
- W3082136623 cites W2076173688 @default.
- W3082136623 cites W2076421666 @default.
- W3082136623 cites W2076776295 @default.
- W3082136623 cites W2081636793 @default.
- W3082136623 cites W2082466238 @default.
- W3082136623 cites W2083932876 @default.
- W3082136623 cites W2084293556 @default.
- W3082136623 cites W2085042325 @default.
- W3082136623 cites W2087291502 @default.
- W3082136623 cites W2087797033 @default.
- W3082136623 cites W2094920479 @default.
- W3082136623 cites W2095081868 @default.
- W3082136623 cites W2097762855 @default.
- W3082136623 cites W2097782486 @default.
- W3082136623 cites W2100923989 @default.
- W3082136623 cites W2104136026 @default.
- W3082136623 cites W2108077357 @default.
- W3082136623 cites W2110670561 @default.
- W3082136623 cites W2111239144 @default.
- W3082136623 cites W2117020669 @default.
- W3082136623 cites W2121236410 @default.
- W3082136623 cites W2123346255 @default.
- W3082136623 cites W2128816394 @default.
- W3082136623 cites W2130443006 @default.
- W3082136623 cites W2131613467 @default.
- W3082136623 cites W2132097038 @default.
- W3082136623 cites W2133514604 @default.
- W3082136623 cites W2138872046 @default.
- W3082136623 cites W2142026162 @default.
- W3082136623 cites W2143327145 @default.
- W3082136623 cites W2146451177 @default.
- W3082136623 cites W2146629016 @default.
- W3082136623 cites W2147014530 @default.
- W3082136623 cites W2150951404 @default.
- W3082136623 cites W2153853960 @default.
- W3082136623 cites W2157447805 @default.
- W3082136623 cites W2158185401 @default.
- W3082136623 cites W2159582658 @default.
- W3082136623 cites W2162463661 @default.
- W3082136623 cites W2163219293 @default.
- W3082136623 cites W2167276353 @default.
- W3082136623 cites W2168137881 @default.
- W3082136623 cites W2169061872 @default.
- W3082136623 cites W2171860579 @default.
- W3082136623 cites W2222441419 @default.
- W3082136623 cites W2246238637 @default.
- W3082136623 cites W2311061917 @default.
- W3082136623 cites W2346271441 @default.
- W3082136623 cites W2409269525 @default.
- W3082136623 cites W2416301049 @default.
- W3082136623 cites W2477767583 @default.