Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082138527> ?p ?o ?g. }
- W3082138527 abstract "Abstract Synthetic lethality is a lethal phenomenon in which the occurrence of a single genetic event is tolerable for cell survival, whereas the co-occurrence of multiple genetic events results in cell death. The main obstacle for synthetic lethality lies in the tumor biology heterogeneity and complexity, the inadequate understanding of synthetic lethal interactions, drug resistance, and the challenges regarding screening and clinical translation. Recently, DNA damage response inhibitors are being tested in various trials with promising results. This review will describe the current challenges, development, and opportunities for synthetic lethality in cancer therapy. The characterization of potential synthetic lethal interactions and novel technologies to develop a more effective targeted drug for cancer patients will be explored. Furthermore, this review will discuss the clinical development and drug resistance mechanisms of synthetic lethality in cancer therapy. The ultimate goal of this review is to guide clinicians at selecting patients that will receive the maximum benefits of DNA damage response inhibitors for cancer therapy." @default.
- W3082138527 created "2020-09-08" @default.
- W3082138527 creator A5035878842 @default.
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- W3082138527 creator A5080891156 @default.
- W3082138527 creator A5081006428 @default.
- W3082138527 creator A5088672902 @default.
- W3082138527 date "2020-09-03" @default.
- W3082138527 modified "2023-10-17" @default.
- W3082138527 title "Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation" @default.
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