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• W3082144258 abstract "Abstract Ras association domain-containing protein 5 (RASSF5), one of the prospective biomarkers for tumors, generally plays a crucial role as a tumor suppressor. As deleterious effects can result from functional differences through SNPs, we sought to analyze the most deleterious SNPs of RASSF5 as well as predict the structural changes associated with the mutants that hamper the normal protein–protein interactions. We adopted both sequence and structure based approaches to analyze the SNPs of RASSF5 protein. We also analyzed the putative post translational modification sites as well as the altered protein–protein interactions that encompass various cascades of signals. Out of all the SNPs obtained from the NCBI database, only 25 were considered as highly deleterious by six in silico SNP prediction tools. Among them, upon analyzing the effect of these nsSNPs on the stability of the protein, we found 17 SNPs that decrease the stability. Significant deviation in the energy minimization score was observed in P350R, F321L, and R277W. Besides this, docking analysis confirmed that P350R, A319V, F321L, and R277W reduce the binding affinity of the protein with H-Ras, where P350R shows the most remarkable deviation. Protein–protein interaction analysis revealed that RASSF5 acts as a hub connecting two clusters consisting of 18 proteins and alteration in the RASSF5 may lead to disassociation of several signal cascades. Thus, based on these analyses, our study suggests that the reported functional SNPs may serve as potential targets for different proteomic studies, diagnosis and therapeutic interventions." @default.
• W3082144258 created "2020-09-08" @default.
• W3082144258 creator A5030918111 @default.
• W3082144258 creator A5032347373 @default.
• W3082144258 creator A5039212907 @default.
• W3082144258 date "2020-09-03" @default.
• W3082144258 modified "2023-10-14" @default.
• W3082144258 title "In silico analysis predicting effects of deleterious SNPs of human RASSF5 gene on its structure and functions" @default.
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• W3082144258 doi "https://doi.org/10.1038/s41598-020-71457-1" @default.
• W3082144258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7471297" @default.
• W3082144258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32884013" @default.
• W3082144258 hasPublicationYear "2020" @default.
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• W3082144258 hasAuthorship W3082144258A5030918111 @default.
• W3082144258 hasAuthorship W3082144258A5032347373 @default.

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