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• W3082152004 abstract "Circular RNA, a non-coding RNA that forms a covalently closed continuous loop, exists widely in eukaryotic cells. The biogenesis and biological function of this type of RNA indicate that it can play a crucial role in diseases such as tumors, neural system diseases, and cardiovascular diseases; moreover, this RNA may have great potential use as a biomarker in these diseases. Oral squamous cell carcinoma (OSCC) is a common malignancy in oral surgery that is difficult to cure, metastasizes easily, and has poor prognosis. In this review, we summarize the loop-forming mechanisms and functions of circular RNA and describe the progress of current research in the development of oral cancer.环状RNA（circRNA）是一种在真核生物中广泛存在的闭合环状非编码RNA，其生成机制、生物学功能的研究进展显示环状RNA可能在包括肿瘤、神经系统疾病、心血管疾病的发生发展过程中扮演重要角色，具有作为疾病标志物的潜能。口腔鳞状细胞癌（OSCC）是口腔外科最常见的恶性肿瘤之一，具有难治疗、易转移、预后差等的特点，由于其发生机制尚不明确，从基因层面阻断OSCC尚不能实现。而环状RNA在OSCC领域的研究进展将为OSCC的生物治疗带来新的思路。本文归纳综述了环状RNA的成环机制、生物学功能及在肿瘤尤其是OSCC发展中的研究进展。." @default.
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• W3082152004 date "2020-08-01" @default.
• W3082152004 modified "2023-10-18" @default.
• W3082152004 title "[Research progress on circular RNA in oral squamous cell carcinoma]." @default.
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• W3082152004 doi "https://doi.org/10.7518/hxkq.2020.04.013" @default.
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