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- W3082162714 abstract "Abstract The formation and maintenance of spatial representations within hippocampal cell assemblies is strongly dictated by patterns of inhibition from diverse interneuron populations. Although it is known that inhibitory synaptic strength is malleable, induction of long-term plasticity at distinct inhibitory synapses and its regulation of hippocampal network activity is not well understood. Here, we show that inhibitory synapses from parvalbumin and somatostatin expressing interneurons undergo long-term depression and potentiation respectively (PV-iLTD and SST-iLTP) during physiological activity patterns. Both forms of plasticity rely on T-type calcium channel activation to confer synapse specificity but otherwise employ distinct mechanisms. Since parvalbumin and somatostatin interneurons preferentially target perisomatic and distal dendritic regions respectively of CA1 pyramidal cells, PV-iLTD and SST-iLTP coordinate a reprioritisation of excitatory inputs from entorhinal cortex and CA3. Furthermore, circuit-level modelling reveals that PV-iLTD and SST-iLTP cooperate to stabilise place cells while facilitating representation of multiple unique environments within the hippocampal network." @default.
- W3082162714 created "2020-09-08" @default.
- W3082162714 creator A5022940492 @default.
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- W3082162714 creator A5072294078 @default.
- W3082162714 date "2020-09-02" @default.
- W3082162714 modified "2023-10-06" @default.
- W3082162714 title "Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output" @default.
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- W3082162714 doi "https://doi.org/10.1038/s41467-020-18074-8" @default.
- W3082162714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7467931" @default.
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- W3082162714 hasPublicationYear "2020" @default.
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