Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082163075> ?p ?o ?g. }
- W3082163075 abstract "HIV transmission via genital and colorectal mucosa are the most common routes of dissemination. Here, we explored the effects of free and complement-opsonized HIV on colorectal tissue. Initially, there was higher antiviral responses in the free HIV compared to complement-opsonized virus. The mucosal transcriptional response at 24 hr revealed the involvement of activated T cells, which was mirrored in cellular responses observed at 96 hr in isolated mucosal T cells. Further, HIV exposure led to skewing of T cell phenotypes predominantly to inflammatory CD4+ T cells, that is Th17 and Th1Th17 subsets. Of note, HIV exposure created an environment that altered the CD8+ T cell phenotype, for example expression of regulatory factors, especially when the virions were opsonized with complement factors. Our findings suggest that HIV-opsonization alters the activation and signaling pathways in the colorectal mucosa, which promotes viral establishment by creating an environment that stimulates mucosal T cell activation and inflammatory Th cells." @default.
- W3082163075 created "2020-09-08" @default.
- W3082163075 creator A5022647341 @default.
- W3082163075 creator A5027381607 @default.
- W3082163075 creator A5028962090 @default.
- W3082163075 creator A5036342395 @default.
- W3082163075 creator A5042801011 @default.
- W3082163075 creator A5045550312 @default.
- W3082163075 creator A5050519937 @default.
- W3082163075 creator A5055132039 @default.
- W3082163075 creator A5060400114 @default.
- W3082163075 creator A5089710137 @default.
- W3082163075 creator A5029664968 @default.
- W3082163075 date "2020-09-02" @default.
- W3082163075 modified "2023-10-01" @default.
- W3082163075 title "Complement opsonization of HIV affects primary infection of human colorectal mucosa and subsequent activation of T cells" @default.
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