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- W3082164020 abstract "Photodynamic therapy (PDT) is a medical treatment in which a combination of a photosensitizing drug and visible light causes destruction of selected cells. This chapter deals with the innovations pertaining to drug delivery systems for PDT. It reports the preparation and characterization of polymeric micelles that incorporate protoporphyrin IX (PpIX), a potent photosensitizer, using non-covalent encapsulation and covalent conjugation methods. PDT is a promising treatment modality for cancer. It is based on the concept that photosensitizers, when exposed to light of specific wavelength, generate cytotoxic reactive oxygen species capable of killing tumor cells. In vitro, nanocells containing Avastin (NCA) significantly enhanced cytotoxicity in pancreatic cancer cells. NCA based PDT also significantly improved treatment response in mice that were orthotopically implanted with pancreatic cancer cells. A novel post-loading approach for constructing a multifunctional biodegradable polyacrylamide nanoplatform has been reported for tumor-imaging (fluorescence) and PDT." @default.
- W3082164020 created "2020-09-08" @default.
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- W3082164020 date "2020-08-11" @default.
- W3082164020 modified "2023-10-14" @default.
- W3082164020 title "Biodegradable Nanoparticles for Photodynamic Therapy" @default.
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- W3082164020 doi "https://doi.org/10.1002/9781119143802.ch32" @default.
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