Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082182495> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3082182495 endingPage "111075" @default.
- W3082182495 startingPage "111075" @default.
- W3082182495 abstract "LDLr-/-/ApoB100/100/IGF-II+/- mice are used as a calcific aortic valve disease (CAVD) model. However, normal aortic valve hemodynamics i.e. remotely from CAVD onset and the sex-related differences are poorly known.Four groups of mice, intact males (IM, n = 49) and females (IF, n = 50), castrated males (CxM, n = 79) and ovariectomized females (OxF: 73), underwent a Doppler-echocardiography at 12 weeks of age. Gonadectomy was performed at 8 weeks. Aortic valve assessment using effective orifice area (EOA, using the continuity equation) and peak aortic transvalvular velocity (VPeak) was feasible in 89% of the mice with good to excellent reliability (intraclass correlation coefficients ranging from 0.90 to 0.98, p < 0.001). Mean VPeak was 104 ± 17 cm/s and mean EOA was 1.18*10-2 ± 0.22*10-2 cm2. EOA indexed to body surface area was 1.5 ± 0.3 cm2/m2. The 95th percentile of Vpeak was 132 cm/s and the 5th percentile of indexed EOA was 1.0 cm2/m2. Interestingly, IM had the highest VPeak (114 ± 14 cm/s) vs each of the other groups (CxM: 106 ± 19 cm/s, OxF: 97 ± 13 cm/s and IF: 96 ± 12 cm/s, ANOVA and corrected p < 0.001). This was mostly explained by a higher stroke volume (ANOVA and corrected p < 0.001) in IM compared to other groups. There were no major sex-differences in ventricular systolic function parameters.In LDLr-/-/ApoB100/100/IGF-II CAVD mice model, an aortic EOA <0.8*10-2 cm2 (or indexed EOA <1.0cm2/m2), and a peak aortic valve velocity > 132 cm/s may be proposed as thresholds to define CAVD. Intact male mice appear to have higher velocities." @default.
- W3082182495 created "2020-09-08" @default.
- W3082182495 creator A5007108865 @default.
- W3082182495 creator A5007768979 @default.
- W3082182495 creator A5028748730 @default.
- W3082182495 creator A5047425246 @default.
- W3082182495 creator A5048504581 @default.
- W3082182495 creator A5061667508 @default.
- W3082182495 creator A5067628862 @default.
- W3082182495 creator A5068564216 @default.
- W3082182495 creator A5078590143 @default.
- W3082182495 creator A5085798345 @default.
- W3082182495 creator A5090350974 @default.
- W3082182495 date "2020-10-01" @default.
- W3082182495 modified "2023-10-06" @default.
- W3082182495 title "Sex-differences in echocardiographic assessment of aortic valve in young adult LDLr−/−/ApoB100/100/IGF-II+/− mice" @default.
- W3082182495 cites W1507413178 @default.
- W3082182495 cites W1955064660 @default.
- W3082182495 cites W1969332989 @default.
- W3082182495 cites W1974618259 @default.
- W3082182495 cites W2027378077 @default.
- W3082182495 cites W2037089178 @default.
- W3082182495 cites W2090250999 @default.
- W3082182495 cites W2108996336 @default.
- W3082182495 cites W2117055361 @default.
- W3082182495 cites W2122497790 @default.
- W3082182495 cites W2122694177 @default.
- W3082182495 cites W2124624517 @default.
- W3082182495 cites W2135766637 @default.
- W3082182495 cites W2142971568 @default.
- W3082182495 cites W2235025403 @default.
- W3082182495 cites W2301954279 @default.
- W3082182495 cites W2327037637 @default.
- W3082182495 cites W2548912871 @default.
- W3082182495 cites W2555853970 @default.
- W3082182495 cites W2605115422 @default.
- W3082182495 cites W68457931 @default.
- W3082182495 doi "https://doi.org/10.1016/j.exger.2020.111075" @default.
- W3082182495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32861845" @default.
- W3082182495 hasPublicationYear "2020" @default.
- W3082182495 type Work @default.
- W3082182495 sameAs 3082182495 @default.
- W3082182495 citedByCount "5" @default.
- W3082182495 countsByYear W30821824952020 @default.
- W3082182495 countsByYear W30821824952021 @default.
- W3082182495 countsByYear W30821824952022 @default.
- W3082182495 crossrefType "journal-article" @default.
- W3082182495 hasAuthorship W3082182495A5007108865 @default.
- W3082182495 hasAuthorship W3082182495A5007768979 @default.
- W3082182495 hasAuthorship W3082182495A5028748730 @default.
- W3082182495 hasAuthorship W3082182495A5047425246 @default.
- W3082182495 hasAuthorship W3082182495A5048504581 @default.
- W3082182495 hasAuthorship W3082182495A5061667508 @default.
- W3082182495 hasAuthorship W3082182495A5067628862 @default.
- W3082182495 hasAuthorship W3082182495A5068564216 @default.
- W3082182495 hasAuthorship W3082182495A5078590143 @default.
- W3082182495 hasAuthorship W3082182495A5085798345 @default.
- W3082182495 hasAuthorship W3082182495A5090350974 @default.
- W3082182495 hasConcept C105795698 @default.
- W3082182495 hasConcept C122048520 @default.
- W3082182495 hasConcept C126322002 @default.
- W3082182495 hasConcept C134018914 @default.
- W3082182495 hasConcept C164705383 @default.
- W3082182495 hasConcept C2780714102 @default.
- W3082182495 hasConcept C33923547 @default.
- W3082182495 hasConcept C71924100 @default.
- W3082182495 hasConcept C99476002 @default.
- W3082182495 hasConceptScore W3082182495C105795698 @default.
- W3082182495 hasConceptScore W3082182495C122048520 @default.
- W3082182495 hasConceptScore W3082182495C126322002 @default.
- W3082182495 hasConceptScore W3082182495C134018914 @default.
- W3082182495 hasConceptScore W3082182495C164705383 @default.
- W3082182495 hasConceptScore W3082182495C2780714102 @default.
- W3082182495 hasConceptScore W3082182495C33923547 @default.
- W3082182495 hasConceptScore W3082182495C71924100 @default.
- W3082182495 hasConceptScore W3082182495C99476002 @default.
- W3082182495 hasFunder F4320315578 @default.
- W3082182495 hasFunder F4320333363 @default.
- W3082182495 hasLocation W30821824951 @default.
- W3082182495 hasLocation W30821824952 @default.
- W3082182495 hasOpenAccess W3082182495 @default.
- W3082182495 hasPrimaryLocation W30821824951 @default.
- W3082182495 hasRelatedWork W1964932059 @default.
- W3082182495 hasRelatedWork W1966504330 @default.
- W3082182495 hasRelatedWork W1974041167 @default.
- W3082182495 hasRelatedWork W1979139803 @default.
- W3082182495 hasRelatedWork W2030889776 @default.
- W3082182495 hasRelatedWork W2037631372 @default.
- W3082182495 hasRelatedWork W2040058909 @default.
- W3082182495 hasRelatedWork W2132898409 @default.
- W3082182495 hasRelatedWork W2140569197 @default.
- W3082182495 hasRelatedWork W2748952813 @default.
- W3082182495 hasVolume "140" @default.
- W3082182495 isParatext "false" @default.
- W3082182495 isRetracted "false" @default.
- W3082182495 magId "3082182495" @default.
- W3082182495 workType "article" @default.