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- W308223785 abstract "The dynamic growth of water-soluble aerosols within human respiratory tracts can be significant and may notably alter the transport and deposition of such inhaled aerosols. Moreover, considerable structural changes occur in human respiratory tracts during early ages, leading to further variations in respiratory airflow pattern and aerosol dynamics. This chapter will review some of the latest advances in modeling and simulations of the psychrometric phenomena in human upper airways, examine hygroscopic factors that influence the growth and deposition of inhaled particles, discuss their implications in health assessments of environmental exposure, and demonstrate the applications of aerosol hygroscopic properties to improve inhalation drug delivery efficiency. Characterization of respiratory anatomical variation at different ages based on CT/MRI imaging will be presented. Specifically, psychrometric behaviors of inhaled airflow and hygroscopic aerosols will be examined in three physiological-realistic geometries, which include an adult nose-throat model, a child nose-throat model, and an adult mouth-lung airway model. Results reported in this chapter highlight the particle condensation growth as a potentially significant mechanism in the deposition of fine aerosol particles under saturated inhalation conditions. Furthermore, particle condensation growth possesses a promising implication to improve delivery efficiency targeting either the nasal olfactory region or the lungs. These results are intended to provide guidance in making appropriate exposure risk assessment of environmental pollutants, dose-response predictions of inhaled medications, and in designing targeted respiratory drug delivery systems." @default.
- W308223785 created "2016-06-24" @default.
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- W308223785 date "2015-01-01" @default.
- W308223785 modified "2023-09-29" @default.
- W308223785 title "Characterizing Respiratory Airflow and Aerosol Condensational Growth in Children and Adults Using an Imaging-CFD Approach" @default.
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- W308223785 doi "https://doi.org/10.1016/b978-0-12-408077-5.00005-5" @default.
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