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- W3082244202 abstract "Engineered nano–bio interfaces driven by tunable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Yet the interplay between substrate topography and cellular behavior is highly complex and not fully understood. A new experimental design is proposed that enables generation of ultrathin sections (lamellae) of cell–nanostructure imprints with minimal artifacts. We demonstrate the potential of such lamellae for efficient transmission electron microscopy (TEM) characterization of interfacial interactions between adherent cells and vertically aligned Si nanostructures. This approach will advance understanding of cellular responses to extracellular biophysical and biochemical cues—which is likely to facilitate the design of improved cellular manipulation technologies." @default.
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- W3082244202 date "2020-09-01" @default.
- W3082244202 modified "2023-10-10" @default.
- W3082244202 title "Efficient Transmission Electron Microscopy Characterization of Cell–Nanostructure Interfacial Interactions" @default.
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- W3082244202 doi "https://doi.org/10.1021/jacs.0c05919" @default.
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