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- W3082261885 abstract "Excessive brain iron negatively affects working memory and related processes but the impact of cortical iron on task-relevant, cortical brain networks is unknown. We hypothesized that high cortical iron concentration may disrupt functional circuitry within cortical networks supporting working memory performance. Fifty-five healthy older adults completed an N-Back working memory paradigm while functional magnetic resonance imaging (fMRI) was performed. Participants also underwent quantitative susceptibility mapping (QSM) imaging for assessment of non-heme brain iron concentration. Additionally, pseudo continuous arterial spin labeling scans were obtained to control for potential contributions of cerebral blood volume and structural brain images were used to control for contributions of brain volume. Task performance was positively correlated with strength of task-based functional connectivity (tFC) between brain regions of the frontoparietal working memory network. However, higher cortical iron concentration was associated with lower tFC within this frontoparietal network and with poorer working memory performance after controlling for both cerebral blood flow and brain volume. Our results suggest that high cortical iron concentration disrupts communication within frontoparietal networks supporting working memory and is associated with reduced working memory performance in older adults." @default.
- W3082261885 created "2020-09-08" @default.
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- W3082261885 date "2020-12-01" @default.
- W3082261885 modified "2023-10-15" @default.
- W3082261885 title "Cortical iron disrupts functional connectivity networks supporting working memory performance in older adults" @default.
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- W3082261885 cites W1967922486 @default.
- W3082261885 cites W1971032414 @default.
- W3082261885 cites W1971798829 @default.
- W3082261885 cites W1977308172 @default.
- W3082261885 cites W1979687173 @default.
- W3082261885 cites W1981835221 @default.
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- W3082261885 cites W2002844915 @default.
- W3082261885 cites W2006096283 @default.
- W3082261885 cites W2016519072 @default.
- W3082261885 cites W2017576864 @default.
- W3082261885 cites W2021093821 @default.
- W3082261885 cites W2026406338 @default.
- W3082261885 cites W2029578773 @default.
- W3082261885 cites W2034690693 @default.
- W3082261885 cites W2039436112 @default.
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- W3082261885 doi "https://doi.org/10.1016/j.neuroimage.2020.117309" @default.
- W3082261885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7821351" @default.
- W3082261885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32861788" @default.
- W3082261885 hasPublicationYear "2020" @default.
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