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- W3082293334 abstract "Bacterial pathogens residing in host macrophages in intracellular infections are hard to eradicate because traditional antibiotics do not readily enter the cells or get eliminated via efflux pumps. To overcome this challenge, we developed a new particle formulation with a size amenable to selective macrophage uptake, loaded with two antibacterial agents - pexiganan and silver (Ag) nanoparticles. Here, pexiganan was loaded in 600 nm poly(lactic-co-glycolic acid) (PLGA) particles (NP), and the particle surface was modified with an iron-tannic acid supramolecular complex (pTA) that help attach Ag nanoparticles. PLGA particles coated with Ag (NP-pTA-Ag) were taken up by macrophages, but not by non-phagocytic cells, such as fibroblasts, reducing non-specific toxicity associated with Ag nanoparticles. NP-pTA-Ag loaded with pexiganan ([email protected]) showed more potent antibacterial activity against various intracellular pathogens than NP-pTA-Ag or [email protected] (pexiganan-loaded NP with no Ag), suggesting a collaborative function between pexiganan and Ag nanoparticles. Mouse whole-body imaging demonstrated that, upon intravenous injection, NP-pTA-Ag quickly accumulated in the liver and spleen, where intracellular bacteria tend to reside. These results support that [email protected] is a promising strategy for the treatment of intracellular bacterial infection." @default.
- W3082293334 created "2020-09-08" @default.
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- W3082293334 date "2020-12-01" @default.
- W3082293334 modified "2023-10-12" @default.
- W3082293334 title "Antibacterial nanotruffles for treatment of intracellular bacterial infection" @default.
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- W3082293334 doi "https://doi.org/10.1016/j.biomaterials.2020.120344" @default.
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