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- W3082354025 abstract "Aims: Following Renal transplant, recipients receive a combination of immunosuppressive prophylaxis depending on centre protocol. Whilst these drugs are vital for graft survival, a well-recognised side effect is serum glucose impairment and subsequent new onset diabetes after renal transplantation (NODAT). Methods: Retrospective data was collected and analysed from 110 patients, who underwent a cadaveric or live renal transplant between January 2018 – December 2018. Electronic records were accessed to decipher recipient blood glucose sugars and HbA1C levels at 1 month, 6 months and 12 months post renal transplant. This data was then utilised to establish the rate of glucose impairment and NODAT incidence at these time intervals. Results: Salient study findings are summarised in the table below. Mean (+/- standard deviations) are used unless otherwise specified.Discussion: Total number of renal transplants was 110. The unit has a standard immunosuppressive protocol of simulect 20 mg (day 0,4), Methylprednisolone 500 mg at induction. Maintenance includes Mycophenolate mofetil (500mg BD), and Tacrolimus (Trough levels 6-8) and prednisolone 5mg. The highest average glucose impairment was observed at 1 month following transplant.17 (15.45%) recipients remained diabetic, 67 (60.91%) recipients remained non-diabetic, whilst 7 (6.36%) recipients developed NODAT. Conclusion: Glucose impairment is seen more commonly within the first 6 months of renal transplant, with a NODAT rate of 6.3% per annum. Interestingly, 19 of 110 recipients (17.2%) who were diabetic pre-transplant showed improved glucose metabolism, and consequently required a reduced diabetic treatment regimen. The maintenance dose of steroids seems to have no impact on NODAT rate. Additionally, post-operative care may be enhanced with diabetologist specialist input for managing glucose impairment and NODAT." @default.
- W3082354025 created "2020-09-08" @default.
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- W3082354025 date "2020-09-01" @default.
- W3082354025 modified "2023-09-27" @default.
- W3082354025 title "THE INCIDENCE OF GLUCOSE IMPAIRMENT AND NEW ONSET DIABETES (NODAT) AFTER RENAL TRANSPLANT: A RETROSPECTIVE 12-MONTH REVIEW AT A SINGLE UK-CENTRE." @default.
- W3082354025 doi "https://doi.org/10.1097/01.tp.0000701844.39856.26" @default.
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