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• W3082363184 endingPage "13170" @default.
• W3082363184 startingPage "13156" @default.
• W3082363184 abstract "The presence of DNA in the cytosol is usually a sign of microbial infections, which alerts the host innate immune system to mount a defense response. Cyclic GMP-AMP synthase (cGAS) is a critical cytosolic DNA sensor that elicits robust innate immune responses through the production of the second messenger, cyclic GMP-AMP (cGAMP), which binds and activates stimulator of interferon genes (STING). However, cGAS binds to DNA irrespective of DNA sequence, therefore, self-DNA leaked from the nucleus or mitochondria can also serve as a cGAS ligand to activate this pathway and trigger extensive inflammatory responses. Dysregulation of the cGAS-STING pathway is responsible for a broad array of inflammatory and autoimmune diseases. Recently, evidence has shown that self-DNA release and cGAS-STING pathway over-activation can drive lung disease, making this pathway a promising therapeutic target for inflammatory lung disease. Here, we review recent advances on the cGAS-STING pathway governing self-DNA sensing, highlighting its role in pulmonary disease." @default.
• W3082363184 created "2020-09-08" @default.
• W3082363184 creator A5014883889 @default.
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• W3082363184 creator A5038465774 @default.
• W3082363184 creator A5085011121 @default.
• W3082363184 creator A5087250535 @default.
• W3082363184 date "2020-08-28" @default.
• W3082363184 modified "2023-10-14" @default.
• W3082363184 title "The cGAS‐STING pathway: The role of self‐DNA sensing in inflammatory lung disease" @default.
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