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• W3082400377 abstract "Abstract Background and aims Type 1 diabetes (T1D) is a multifactorial autoimmune disease that combines genetics and environmental factors. The aim of this study is to determine the environmental risk factors and to investigate how virals infections are risks factors for type 1 diabetics whom have HLA DR3/DR4 predisposition in our population. Methods This study includes 233 subjects, 145 diabetics and 88 controls from regions of the extreme western of Algeria. All the informations related to the disease were collected using predesigned questionnaire. Using in silico approach, we attempt to improve the understanding of this analytical result by molecular mimicry, which is associated with the breakdown of several autoimmune pathologies. Results The statistical study showed that history of varicella and measles infection and T1D related inheritance and type 2 diabetes are risk factors for T1D in the population of Tlemcen. We have determined the homologous antigenic regions between the glycoprotein “gE” of the varicella virus, the “hemagglutinin” of measles and the human protein “HSP60” at the level of their sequence and 3D structure. These cross-reactive epitopes bind to MHC class II molecules (HLA DR3/DR4) that predispose to T1D but not to MHC class II molecules (HLA DR2) that protect against T1D. This epitopes induce Th2 cells but only “hemagglutinin” and “Hsp60” can activate Th1 differentiation. This indicates their potential to destroy pancreatic cells β. Conclusion Our study can allow us to adapt biological markers to genetically predisposed T1D and to establish a preventive strategy for healthy genetic predisposed individuals in Tlemcen population." @default.
• W3082400377 created "2020-09-08" @default.
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• W3082400377 date "2020-11-01" @default.
• W3082400377 modified "2023-10-16" @default.
• W3082400377 title "Molecular mimicry between varicella, measles virus and Hsp60 in type 1 diabetes associated HLA-DR3/DR4 molecules" @default.
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• W3082400377 cites W1981106544 @default.
• W3082400377 cites W1985311187 @default.
• W3082400377 cites W1988689462 @default.
• W3082400377 cites W1990204841 @default.
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• W3082400377 cites W2008841836 @default.
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• W3082400377 doi "https://doi.org/10.1016/j.dsx.2020.08.009" @default.
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