FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082402293> ?p ?o ?g. }

• W3082402293 abstract "Abstract Background Anti-ribosomal P (anti-Rib-P) antibody is a specific serological marker for systemic lupus erythematosus (SLE) and routinely tested by targeting the common epitope of three ribosomal proteins of P0, P1 and P2. This study aimed to investigate if testing antibodies against individual ribosomal protein, but not the common epitope, is required to achieve the best diagnostic benefit in SLE. Methods The study included 82 patients with SLE and 22 healthy donors. Serum antibodies were determined by ELISA and immunoblot. Results The prevalence of each antibody determined by ELISA was 35.4% (anti-Rib-P), 45.1% (anti-Rib-P0), 32.9% (anti-Rib-P1) and 40.2% (anti-Rib-P2) at 99% specificity, respectively. Of 53 patients with negative anti-Rib-P antibody, 21 (39.6%) were positive for anti-Rib-P0, 9 (17.0%) for anti-Rib-P1 and 12 (22.6%) for anti-Rib-P2 antibody. The positive rate of anti-Rib-P antibody detected by ELISA was close to the results by immunoblot (33.4%). Patients with any of these antibodies were featured by higher disease activity and prevalence of skin rashes than those with negative antibodies. Moreover, each antibody was particularly related to some clinical and laboratory disorders. The distribution of subclasses of IgG1–4 was varied with each antibody. Anti-Rib-P0 IgG1 and IgG3 were strongly correlated with disease activity and lower serum complement components 3 and 4. Conclusions Anti-Rib-P antibody is not adequate to predict the existence of antibodies against ribosomal P0, P1 and P2 protein. The examination of antibodies against each ribosomal protein is required to achieve additional diagnostic benefit and to evaluate the association with clinical and serological disorders as well." @default.
• W3082402293 created "2020-09-08" @default.
• W3082402293 creator A5001064189 @default.
• W3082402293 creator A5031551361 @default.
• W3082402293 creator A5032871667 @default.
• W3082402293 creator A5040152914 @default.
• W3082402293 creator A5043328095 @default.
• W3082402293 creator A5062708755 @default.
• W3082402293 creator A5066604715 @default.
• W3082402293 creator A5088579856 @default.
• W3082402293 date "2020-08-28" @default.
• W3082402293 modified "2023-10-14" @default.
• W3082402293 title "The diagnostic benefit of antibodies against ribosomal proteins in systemic lupus erythematosus" @default.
• W3082402293 cites W1596434448 @default.
• W3082402293 cites W1903721099 @default.
• W3082402293 cites W1969018352 @default.
• W3082402293 cites W2025148846 @default.
• W3082402293 cites W2026241336 @default.
• W3082402293 cites W2064999867 @default.
• W3082402293 cites W2070527591 @default.
• W3082402293 cites W2078344511 @default.
• W3082402293 cites W2079258705 @default.
• W3082402293 cites W2091243777 @default.
• W3082402293 cites W2102707929 @default.
• W3082402293 cites W2109039091 @default.
• W3082402293 cites W2126143555 @default.
• W3082402293 cites W2127194984 @default.
• W3082402293 cites W2132623766 @default.
• W3082402293 cites W2140451705 @default.
• W3082402293 cites W2144822844 @default.
• W3082402293 cites W2153319819 @default.
• W3082402293 cites W2168341232 @default.
• W3082402293 cites W2329218002 @default.
• W3082402293 cites W2331928366 @default.
• W3082402293 cites W2607099202 @default.
• W3082402293 cites W2768466576 @default.
• W3082402293 doi "https://doi.org/10.1186/s42358-020-00148-2" @default.
• W3082402293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32859277" @default.
• W3082402293 hasPublicationYear "2020" @default.
• W3082402293 type Work @default.
• W3082402293 sameAs 3082402293 @default.
• W3082402293 citedByCount "3" @default.
• W3082402293 countsByYear W30824022932021 @default.
• W3082402293 countsByYear W30824022932022 @default.
• W3082402293 countsByYear W30824022932023 @default.
• W3082402293 crossrefType "journal-article" @default.
• W3082402293 hasAuthorship W3082402293A5001064189 @default.
• W3082402293 hasAuthorship W3082402293A5031551361 @default.
• W3082402293 hasAuthorship W3082402293A5032871667 @default.
• W3082402293 hasAuthorship W3082402293A5040152914 @default.
• W3082402293 hasAuthorship W3082402293A5043328095 @default.
• W3082402293 hasAuthorship W3082402293A5062708755 @default.
• W3082402293 hasAuthorship W3082402293A5066604715 @default.
• W3082402293 hasAuthorship W3082402293A5088579856 @default.
• W3082402293 hasBestOaLocation W30824022931 @default.
• W3082402293 hasConcept C104317684 @default.
• W3082402293 hasConcept C142724271 @default.
• W3082402293 hasConcept C159654299 @default.
• W3082402293 hasConcept C195616568 @default.
• W3082402293 hasConcept C203014093 @default.
• W3082402293 hasConcept C2776912625 @default.
• W3082402293 hasConcept C2778674544 @default.
• W3082402293 hasConcept C2779134260 @default.
• W3082402293 hasConcept C2780648854 @default.
• W3082402293 hasConcept C45189115 @default.
• W3082402293 hasConcept C55493867 @default.
• W3082402293 hasConcept C67905577 @default.
• W3082402293 hasConcept C71924100 @default.
• W3082402293 hasConcept C86803240 @default.
• W3082402293 hasConceptScore W3082402293C104317684 @default.
• W3082402293 hasConceptScore W3082402293C142724271 @default.
• W3082402293 hasConceptScore W3082402293C159654299 @default.
• W3082402293 hasConceptScore W3082402293C195616568 @default.
• W3082402293 hasConceptScore W3082402293C203014093 @default.
• W3082402293 hasConceptScore W3082402293C2776912625 @default.
• W3082402293 hasConceptScore W3082402293C2778674544 @default.
• W3082402293 hasConceptScore W3082402293C2779134260 @default.
• W3082402293 hasConceptScore W3082402293C2780648854 @default.
• W3082402293 hasConceptScore W3082402293C45189115 @default.
• W3082402293 hasConceptScore W3082402293C55493867 @default.
• W3082402293 hasConceptScore W3082402293C67905577 @default.
• W3082402293 hasConceptScore W3082402293C71924100 @default.
• W3082402293 hasConceptScore W3082402293C86803240 @default.
• W3082402293 hasFunder F4320321001 @default.
• W3082402293 hasFunder F4320321921 @default.
• W3082402293 hasIssue "1" @default.
• W3082402293 hasLocation W30824022931 @default.
• W3082402293 hasLocation W30824022932 @default.
• W3082402293 hasLocation W30824022933 @default.
• W3082402293 hasOpenAccess W3082402293 @default.
• W3082402293 hasPrimaryLocation W30824022931 @default.
• W3082402293 hasRelatedWork W2152005957 @default.
• W3082402293 hasRelatedWork W2422473926 @default.
• W3082402293 hasRelatedWork W2918673775 @default.
• W3082402293 hasRelatedWork W3174229172 @default.
• W3082402293 hasRelatedWork W3215222621 @default.
• W3082402293 hasRelatedWork W4200422002 @default.
• W3082402293 hasRelatedWork W4210810377 @default.
• W3082402293 hasRelatedWork W4378745795 @default.
• W3082402293 hasRelatedWork W66109366 @default.

• next