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- W3082440252 abstract "Cells within the tissue preferentially form a network that works together to carry out a specific function. Thus, the role of a tissue is affected by its cell types as well as the architecture of cellular interactions. A question is to what degree the spatial organization of these cells affects the function of the tissue. We first propose a set of methodologies to analyze the multi-cellular structure of tissues at both local and global scale. The goal is to analyze, formalize, and model the spatial organization of the tissue captured by fluorescence microscopy images. At the local scale, we investigate the spatial relationship of several structures with both direct and indirect cellular interactions. At the global scale, we apply spatial statistic approaches to investigate the degree of randomness of the cell distribution. In addition, an open source toolbox is developed which allows researchers to perform investigations of the position of different cells within a 3D multicellular structure. We apply the toolbox to study of the spatial organization of the islet of Langerhans, a special kind of tissue that plays an important role in regulating the blood glucose level. With a good segmentation accuracy, we have been able to perform our analysis of the islets of Langerhans on several different species such as mouse and monkey. We also utilize our toolbox to explore the structural-functional mechanism of the delta cell, a specific kind of cell within the islet whose role has not yet been determined, but could potentially influence the islet function, in mouse and human. Our generic toolbox is implemented with unbiased analytical capabilities in software platform ImageJ." @default.
- W3082440252 created "2020-09-08" @default.
- W3082440252 creator A5061450407 @default.
- W3082440252 date "2018-01-30" @default.
- W3082440252 modified "2023-09-23" @default.
- W3082440252 title "Analysis and modelling of spatial organization of 3D tissues in biological images" @default.
- W3082440252 hasPublicationYear "2018" @default.
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