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- W3082476543 abstract "ABSTRACT Economic choice necessarily involves the transformation of abstract, object-based representations to concrete, action-based ones. This transformation is both determined and delimited by the neuroanatomical organization of the regions that implement it. In choice, the orbitofrontal cortex (OFC) plays a key role in both abstract valuation and cognitive mapping. However, determining the neural processes underlying this transformation has proven difficult. We hypothesized that difficulty stems from in part from the fact that the OFC consists of multiple functionally distinct zones that are distinguished by their differing contributions to the abstract-concrete transformation, and that these functions reflect their differing long-range projections. Here we identify two such subregions, defined by stronger or weaker bidirectional anatomical connectivity with the posterior cingulate cortex (PCC). We call these regions OFC in and OFC out , respectively. We find that OFC in , relative to OFC out , shows enhanced functional connectivity with PCC, as indicated by both spike-field coherence and mutual information. We find converging evidence that the OFC in -PCC circuit, but not the OFC out -PCC circuit, relays choice signals from an abstract value space to a concrete action space. Moreover, the OFC in -PCC circuit shows a putative bidirectional mutually excitatory pattern. Together, these results support the hypothesis that OFC-PCC subareal organization is critical for understanding the implementation of offer-action transformation in economic choice." @default.
- W3082476543 created "2020-09-08" @default.
- W3082476543 creator A5052131530 @default.
- W3082476543 creator A5057011028 @default.
- W3082476543 creator A5072933482 @default.
- W3082476543 date "2020-09-01" @default.
- W3082476543 modified "2023-10-17" @default.
- W3082476543 title "Anatomically distinct OFC-PCC circuits relay choice from value space to action space" @default.
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- W3082476543 cites W1981036614 @default.
- W3082476543 cites W1991415819 @default.
- W3082476543 cites W1995007954 @default.
- W3082476543 cites W1995156698 @default.
- W3082476543 cites W1999387961 @default.
- W3082476543 cites W2006304614 @default.
- W3082476543 cites W2007495909 @default.
- W3082476543 cites W2015029893 @default.
- W3082476543 cites W2020689320 @default.
- W3082476543 cites W2021251760 @default.
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- W3082476543 cites W2027288486 @default.
- W3082476543 cites W2035462451 @default.
- W3082476543 cites W2047125104 @default.
- W3082476543 cites W2047431381 @default.
- W3082476543 cites W2053576047 @default.
- W3082476543 cites W2058255813 @default.
- W3082476543 cites W2059005805 @default.
- W3082476543 cites W2073934958 @default.
- W3082476543 cites W2081564348 @default.
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- W3082476543 cites W2144421443 @default.
- W3082476543 cites W2151442629 @default.
- W3082476543 cites W2152848035 @default.
- W3082476543 cites W2153693979 @default.
- W3082476543 cites W2169561465 @default.
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- W3082476543 cites W2170968594 @default.
- W3082476543 cites W2178225550 @default.
- W3082476543 cites W2188530842 @default.
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- W3082476543 cites W2409491527 @default.
- W3082476543 cites W2412783075 @default.
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- W3082476543 cites W2794284939 @default.
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- W3082476543 doi "https://doi.org/10.1101/2020.09.01.277889" @default.
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