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• W3082483555 abstract "QPX7728 is a recently discovered ultra-broad-spectrum beta-lactamase inhibitor (BLI) with potent inhibition of key serine and metallo-beta-lactamases. QPX7728 enhances the potency of many beta-lactams, including carbapenems, in beta-lactamase-producing Gram-negative bacteria, including Acinetobacter spp. The potency of meropenem alone and in combination with QPX7728 (1 to 16 μg/ml) was tested against 275 clinical isolates of Acinetobacter baumannii (carbapenem-resistant A. baumannii [CRAB]) collected worldwide that were highly resistant to carbapenems (MIC 50 and MIC 90 for meropenem, 64 and >64 μg/ml)." @default.
• W3082483555 created "2020-09-08" @default.
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• W3082483555 date "2020-10-20" @default.
• W3082483555 modified "2023-10-11" @default.
• W3082483555 title "<i>In Vitro</i> Activity of the Ultra-Broad-Spectrum Beta-Lactamase Inhibitor QPX7728 in Combination with Meropenem against Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii" @default.
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• W3082483555 doi "https://doi.org/10.1128/aac.01406-20" @default.
• W3082483555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7577151" @default.
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