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- W3082490941 endingPage "13354" @default.
- W3082490941 startingPage "13330" @default.
- W3082490941 abstract "Giardia parasites are ubiquitous protozoans of global importance that impact a wide range of animals including humans. They are the most common enteric pathogen of cats and dogs in developed countries and infect ∼1 billion people worldwide. While Giardia infections can be asymptomatic, they often result in severe and chronic diseases. There is also mounting evidence that they are linked to postinfection disorders. Despite growing evidence of the widespread morbidity associated with Giardia infections, current treatment options are limited to compound classes with broad antimicrobial activity. Frontline anti-Giardia drugs are also associated with increasing drug resistance and treatment failures. To improve the health and well-being of millions, new selective anti-Giardia drugs are needed alongside improved health education initiatives. Here we discuss current treatment options together with recent advances and gaps in drug discovery. We also propose criteria to guide the discovery of new anti-Giardia compounds." @default.
- W3082490941 created "2020-09-08" @default.
- W3082490941 creator A5016550301 @default.
- W3082490941 creator A5054757203 @default.
- W3082490941 creator A5055545983 @default.
- W3082490941 creator A5086453804 @default.
- W3082490941 date "2020-09-01" @default.
- W3082490941 modified "2023-10-09" @default.
- W3082490941 title "Anti-<i>Giardia</i> Drug Discovery: Current Status and Gut Feelings" @default.
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