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- W3082492144 endingPage "658" @default.
- W3082492144 startingPage "658" @default.
- W3082492144 abstract "Prostate cancer (PCa) is one of the most frequently diagnosed malignancies, and the fifth leading cause of cancer related mortality in men. For advanced PCa, radical prostatectomy, radiotherapy, and/or long-term androgen deprivation therapy are the recommended treatment options. However, subsequent progression to metastatic disease after initial therapy results in low 5-year survival rates (29%). Omics technologies enable the acquisition of high-resolution large datasets that can provide insights into molecular mechanisms underlying PCa pathology. For the purpose of this article, a systematic literature search was conducted through the Web of Science Database to critically evaluate recent omics-driven studies that were performed towards: (a) Biomarker development and (b) characterization of novel molecular-based therapeutic targets. The results indicate that multiple omics-based biomarkers with prognostic and predictive value have been validated in the context of PCa, with several of those being also available for commercial use. At the same time, omics-driven potential drug targets have been investigated in pre-clinical settings and even in clinical trials, holding the promise for improved clinical management of advanced PCa, as part of personalized medicine pipelines." @default.
- W3082492144 created "2020-09-08" @default.
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- W3082492144 date "2020-08-31" @default.
- W3082492144 modified "2023-10-18" @default.
- W3082492144 title "Omics Derived Biomarkers and Novel Drug Targets for Improved Intervention in Advanced Prostate Cancer" @default.
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- W3082492144 doi "https://doi.org/10.3390/diagnostics10090658" @default.
- W3082492144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7555799" @default.
- W3082492144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32878288" @default.
- W3082492144 hasPublicationYear "2020" @default.
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