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• W3082499308 abstract "BackgroundElevated extracellular DNA levels are found in the sputum of patients with cystic fibrosis (CF). However, studies investigating the association of extracellular DNA with CF severity are scarce.ObjectiveTo evaluate the association of extracellular DNA levels with pulmonary function, antibiotic use, and hospitalization in CF patients.MethodsThis cross-sectional study included CF patients aged ≥5 years who were clinically stable and produced spontaneously expectorated sputum. Extracellular DNA in sputum was quantified, and extracellular DNA networks were seen with immunofluorescence microscopy. Also, cell death profile was assessed. Data on pulmonary function, airway colonization, antibiotic use, and hospitalization in the previous year were collected. Patients were divided into two groups based on median DNA level.ResultsThirty-three patients were included. Their mean age was 16.3 ± 6.2 years, mean forced expiratory volume in the first second (FEV1) was 67.0 ± 26.7 (% of the predicted), and mean DNA level was 241.9 ± 147.2 μg/mL. There were significant correlations of DNA level with FEV1 (r = −0.60; p < 0.001) and forced vital capacity (r = −0.59; p < 0.001). Moreover, patients with higher DNA level (>243.0 μg/mL) had lower FEV1 (52.1 ± 27.8% vs. 81.1 ± 16.2%; p = 0.001) and required more hospitalizations (68.8% vs. 35.3%; p = 0.05). Additional findings were the presence of extracellular DNA networks and low rates of necrosis and apoptosis.ConclusionElevated extracellular DNA levels in CF sputum are associated with reduced pulmonary function and increased hospitalizations." @default.
• W3082499308 created "2020-09-08" @default.
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• W3082499308 date "2020-10-01" @default.
• W3082499308 modified "2023-10-17" @default.
• W3082499308 title "Extracellular DNA in sputum is associated with pulmonary function and hospitalization in patients with cystic fibrosis" @default.
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• W3082499308 doi "https://doi.org/10.1016/j.rmed.2020.106144" @default.
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