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• W3082505468 endingPage "4012" @default.
• W3082505468 startingPage "4012" @default.
• W3082505468 abstract "Identified in 1973, somatostatin (SST) is a cyclic hormone peptide with a short biological half-life. Somatostatin receptors (SSTRs) are widely expressed in the whole body, with five subtypes described. The interaction between SST and its receptors leads to the internalization of the ligand–receptor complex and triggers different cellular signaling pathways. Interestingly, the expression of SSTRs is significantly enhanced in many solid tumors, especially gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). Thus, somatostatin analogs (SSAs) have been developed to improve the stability of the endogenous ligand and so extend its half-life. Radiolabeled analogs have been developed with several radioelements such as indium-111, technetium-99 m, and recently gallium-68, fluorine-18, and copper-64, to visualize the distribution of receptor overexpression in tumors. Internal metabolic radiotherapy is also used as a therapeutic strategy (e.g., using yttrium-90, lutetium-177, and actinium-225). With some radiopharmaceuticals now used in clinical practice, somatostatin analogs developed for imaging and therapy are an example of the concept of personalized medicine with a theranostic approach. Here, we review the development of these analogs, from the well-established and authorized ones to the most recently developed radiotracers, which have better pharmacokinetic properties and demonstrate increased efficacy and safety, as well as the search for new clinical indications." @default.
• W3082505468 created "2020-09-08" @default.
• W3082505468 creator A5032410140 @default.
• W3082505468 creator A5036923858 @default.
• W3082505468 creator A5043209605 @default.
• W3082505468 creator A5047451387 @default.
• W3082505468 creator A5067207010 @default.
• W3082505468 creator A5088831248 @default.
• W3082505468 date "2020-09-02" @default.
• W3082505468 modified "2023-10-18" @default.
• W3082505468 title "Overview of Radiolabeled Somatostatin Analogs for Cancer Imaging and Therapy" @default.
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