Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082510532> ?p ?o ?g. }
- W3082510532 abstract "Inflammation triggered by metabolic imbalance, also called metainflammation, is low-grade inflammation caused by the components involved in metabolic syndrome (MetS), including central obesity and impaired glucose tolerance. This phenomenon is mainly due to excess nutrients and energy, and it contributes to the pathogenesis of osteoarthritis (OA). OA is characterized by the progressive degeneration of articular cartilage, which suffers erosion and progressively becomes thinner. Purinergic signaling is involved in several physiological and pathological processes, such as cell proliferation in development and tissue regeneration, neurotransmission and inflammation. Adenosine and ATP receptors, and other members of the signaling pathway, such as AMP-activated protein kinase (AMPK), are involved in obesity, type 2 diabetes (T2D) and OA progression. In this review, we focus on purinergic regulation in osteoarthritic cartilage and how different components of MetS, such as obesity and T2D, modulate the purinergic system in OA. In that regard, we describe the critical role in this disease of receptors, such as adenosine A2A receptor (A2AR) and ATP P2X7 receptor. Finally, we also assess how nucleotides regulate the inflammasome in OA." @default.
- W3082510532 created "2020-09-08" @default.
- W3082510532 creator A5008041383 @default.
- W3082510532 creator A5009929476 @default.
- W3082510532 creator A5023683621 @default.
- W3082510532 creator A5050993058 @default.
- W3082510532 creator A5072985075 @default.
- W3082510532 creator A5081324051 @default.
- W3082510532 creator A5089589231 @default.
- W3082510532 date "2020-08-28" @default.
- W3082510532 modified "2023-09-26" @default.
- W3082510532 title "Purinergic System Signaling in Metainflammation-Associated Osteoarthritis" @default.
- W3082510532 cites W1003328916 @default.
- W3082510532 cites W104784717 @default.
- W3082510532 cites W134848280 @default.
- W3082510532 cites W1593467689 @default.
- W3082510532 cites W1595299996 @default.
- W3082510532 cites W1792542720 @default.
- W3082510532 cites W1804408139 @default.
- W3082510532 cites W1836406968 @default.
- W3082510532 cites W1908273252 @default.
- W3082510532 cites W1919236313 @default.
- W3082510532 cites W1932870409 @default.
- W3082510532 cites W1948268265 @default.
- W3082510532 cites W1964162666 @default.
- W3082510532 cites W1965316405 @default.
- W3082510532 cites W1966336914 @default.
- W3082510532 cites W1966652886 @default.
- W3082510532 cites W1968714897 @default.
- W3082510532 cites W1969233019 @default.
- W3082510532 cites W1969307566 @default.
- W3082510532 cites W1969883571 @default.
- W3082510532 cites W1969984411 @default.
- W3082510532 cites W1971084572 @default.
- W3082510532 cites W1971139360 @default.
- W3082510532 cites W1975396356 @default.
- W3082510532 cites W1977139899 @default.
- W3082510532 cites W1977897934 @default.
- W3082510532 cites W1978542049 @default.
- W3082510532 cites W1978782142 @default.
- W3082510532 cites W1979412100 @default.
- W3082510532 cites W1981310325 @default.
- W3082510532 cites W1985407729 @default.
- W3082510532 cites W1986349550 @default.
- W3082510532 cites W1990630360 @default.
- W3082510532 cites W1991532350 @default.
- W3082510532 cites W1995167724 @default.
- W3082510532 cites W1995321301 @default.
- W3082510532 cites W1995854833 @default.
- W3082510532 cites W1996087219 @default.
- W3082510532 cites W1996216848 @default.
- W3082510532 cites W1996477186 @default.
- W3082510532 cites W1999269526 @default.
- W3082510532 cites W1999438537 @default.
- W3082510532 cites W2000054651 @default.
- W3082510532 cites W2000104936 @default.
- W3082510532 cites W2000657398 @default.
- W3082510532 cites W2001436617 @default.
- W3082510532 cites W2002247748 @default.
- W3082510532 cites W2002811082 @default.
- W3082510532 cites W2004104974 @default.
- W3082510532 cites W2006406278 @default.
- W3082510532 cites W2010167659 @default.
- W3082510532 cites W2010500550 @default.
- W3082510532 cites W2014140858 @default.
- W3082510532 cites W2018585106 @default.
- W3082510532 cites W2022093304 @default.
- W3082510532 cites W2022159206 @default.
- W3082510532 cites W2022268303 @default.
- W3082510532 cites W2022494133 @default.
- W3082510532 cites W2023135418 @default.
- W3082510532 cites W2023403956 @default.
- W3082510532 cites W2025212116 @default.
- W3082510532 cites W2026522326 @default.
- W3082510532 cites W2027831505 @default.
- W3082510532 cites W2031470785 @default.
- W3082510532 cites W2032210749 @default.
- W3082510532 cites W2034321048 @default.
- W3082510532 cites W2035915584 @default.
- W3082510532 cites W2036752543 @default.
- W3082510532 cites W2038351882 @default.
- W3082510532 cites W2039327347 @default.
- W3082510532 cites W2039844197 @default.
- W3082510532 cites W2049893029 @default.
- W3082510532 cites W2052663559 @default.
- W3082510532 cites W2053382677 @default.
- W3082510532 cites W2053737173 @default.
- W3082510532 cites W2054001111 @default.
- W3082510532 cites W2054310788 @default.
- W3082510532 cites W2055150344 @default.
- W3082510532 cites W2056244474 @default.
- W3082510532 cites W2056566535 @default.
- W3082510532 cites W2057780728 @default.
- W3082510532 cites W2058852263 @default.
- W3082510532 cites W2060106966 @default.
- W3082510532 cites W2060642773 @default.
- W3082510532 cites W2062756785 @default.
- W3082510532 cites W2063347675 @default.
- W3082510532 cites W2064482881 @default.
- W3082510532 cites W2065403468 @default.