Matches in SemOpenAlex for { <https://semopenalex.org/work/W3082520281> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3082520281 endingPage "101546" @default.
- W3082520281 startingPage "101546" @default.
- W3082520281 abstract "In susceptible hosts, protection from Leptospira infection is mediated by the innate immune response at the point of entry and humoral immunity. Thus, identifying and segregating the initial host response at the representative host-pathogen interface is needed to understand the typical outcomes of Leptospira infection, clearance, persistence, or disease. An in vitro whole blood culture system to study the overall immune response using pathogenic and non-pathogenic Leptospira strains was explored in this study. Using an ELISA, increased IL-8, TNF alpha, and IL-1 in blood samples stimulated with pathogenic and nonpathogenic Leptospira compared to unstimulated controls were detected. In RT2 Profiler PCR Array assays, consistent upregulation of 22 genes and downregulation of 25 genes were observed. Few of the notable upregulated genes included BPI, CCL3, CXCL2, IL-6, IL-8, TLR1, TLR2, TLR6, and TNF and downregulated genes included, LBP, LYZ, MPO, MYD88. IFNβ was upregulated in samples treated with pathogenic Leptospira and IL-1β was upregulated in samples treated with nonpathogenic Leptospira. Toll- like Receptor signaling and expression of pattern recognition receptors were two of the five prominent canonical pathways observed. Individual deconvolution of each of the specific and significant pathways observed in this study may improve the understanding of the pathogenesis of this important zoonotic agent. The use of this system in conjunction with whole transcriptome analysis in a larger population, may unveil the robust nature of host/Leptospira interaction." @default.
- W3082520281 created "2020-09-08" @default.
- W3082520281 creator A5019015311 @default.
- W3082520281 creator A5019973734 @default.
- W3082520281 creator A5041486037 @default.
- W3082520281 date "2020-12-01" @default.
- W3082520281 modified "2023-09-30" @default.
- W3082520281 title "Potential use of a canine whole blood culture system to evaluate the immune response to Leptospira" @default.
- W3082520281 cites W1527612695 @default.
- W3082520281 cites W1907048705 @default.
- W3082520281 cites W1927641937 @default.
- W3082520281 cites W1984830992 @default.
- W3082520281 cites W1997961868 @default.
- W3082520281 cites W2020663709 @default.
- W3082520281 cites W2062835892 @default.
- W3082520281 cites W2105461608 @default.
- W3082520281 cites W2164917224 @default.
- W3082520281 cites W2168442400 @default.
- W3082520281 cites W2511900031 @default.
- W3082520281 cites W2807482435 @default.
- W3082520281 doi "https://doi.org/10.1016/j.cimid.2020.101546" @default.
- W3082520281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32916553" @default.
- W3082520281 hasPublicationYear "2020" @default.
- W3082520281 type Work @default.
- W3082520281 sameAs 3082520281 @default.
- W3082520281 citedByCount "4" @default.
- W3082520281 countsByYear W30825202812022 @default.
- W3082520281 countsByYear W30825202812023 @default.
- W3082520281 crossrefType "journal-article" @default.
- W3082520281 hasAuthorship W3082520281A5019015311 @default.
- W3082520281 hasAuthorship W3082520281A5019973734 @default.
- W3082520281 hasAuthorship W3082520281A5041486037 @default.
- W3082520281 hasConcept C10389963 @default.
- W3082520281 hasConcept C104317684 @default.
- W3082520281 hasConcept C127561419 @default.
- W3082520281 hasConcept C136449434 @default.
- W3082520281 hasConcept C150194340 @default.
- W3082520281 hasConcept C162317418 @default.
- W3082520281 hasConcept C193419808 @default.
- W3082520281 hasConcept C203014093 @default.
- W3082520281 hasConcept C2780542935 @default.
- W3082520281 hasConcept C2781236682 @default.
- W3082520281 hasConcept C2908647359 @default.
- W3082520281 hasConcept C54355233 @default.
- W3082520281 hasConcept C71924100 @default.
- W3082520281 hasConcept C86803240 @default.
- W3082520281 hasConcept C8891405 @default.
- W3082520281 hasConcept C89423630 @default.
- W3082520281 hasConcept C99454951 @default.
- W3082520281 hasConceptScore W3082520281C10389963 @default.
- W3082520281 hasConceptScore W3082520281C104317684 @default.
- W3082520281 hasConceptScore W3082520281C127561419 @default.
- W3082520281 hasConceptScore W3082520281C136449434 @default.
- W3082520281 hasConceptScore W3082520281C150194340 @default.
- W3082520281 hasConceptScore W3082520281C162317418 @default.
- W3082520281 hasConceptScore W3082520281C193419808 @default.
- W3082520281 hasConceptScore W3082520281C203014093 @default.
- W3082520281 hasConceptScore W3082520281C2780542935 @default.
- W3082520281 hasConceptScore W3082520281C2781236682 @default.
- W3082520281 hasConceptScore W3082520281C2908647359 @default.
- W3082520281 hasConceptScore W3082520281C54355233 @default.
- W3082520281 hasConceptScore W3082520281C71924100 @default.
- W3082520281 hasConceptScore W3082520281C86803240 @default.
- W3082520281 hasConceptScore W3082520281C8891405 @default.
- W3082520281 hasConceptScore W3082520281C89423630 @default.
- W3082520281 hasConceptScore W3082520281C99454951 @default.
- W3082520281 hasLocation W30825202811 @default.
- W3082520281 hasOpenAccess W3082520281 @default.
- W3082520281 hasPrimaryLocation W30825202811 @default.
- W3082520281 hasRelatedWork W1175477002 @default.
- W3082520281 hasRelatedWork W1578468597 @default.
- W3082520281 hasRelatedWork W1914689199 @default.
- W3082520281 hasRelatedWork W2082627135 @default.
- W3082520281 hasRelatedWork W2086739630 @default.
- W3082520281 hasRelatedWork W2141330728 @default.
- W3082520281 hasRelatedWork W2165610050 @default.
- W3082520281 hasRelatedWork W2364577086 @default.
- W3082520281 hasRelatedWork W2884963187 @default.
- W3082520281 hasRelatedWork W3140535742 @default.
- W3082520281 hasVolume "73" @default.
- W3082520281 isParatext "false" @default.
- W3082520281 isRetracted "false" @default.
- W3082520281 magId "3082520281" @default.
- W3082520281 workType "article" @default.