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• W3082523213 endingPage "913" @default.
• W3082523213 startingPage "902" @default.
• W3082523213 abstract "Level of adherence to tobacco cessation medication regimens is believed to be causally related to medication effectiveness. This study aimed to evaluate the efficacy of varenicline directly observed therapy (DOT) on varenicline adherence and smoking cessation rates among smokers with opioid use disorder (OUD) receiving methadone treatment.Multicenter, parallel-group two-arm randomized controlled trial.Urban opioid treatment program (OTP) in the Bronx, New York, USA.Daily smokers of ≥ 5 cigarettes/day, interested in quitting (ladder of change score 6-8), in methadone treatment for ≥ 3 months, attending OTP ≥ 3 days/week. Participants' mean age was 49 years, 56% were male, 44% Latino, 30% Black, and they smoked a median of 10 cigarettes/day.Individual, block, random assignment to 12 weeks of varenicline, either directly observed with methadone (DOT, n = 50) or via unsupervised self-administered treatment (SAT, n = 50).The primary outcome was adherence measured by pill count. The secondary outcome was 7-day point prevalence tobacco abstinence verified by expired carbon monoxide (CO) < 8 parts per million.Retention at 24 weeks was 92%. Mean adherence was 78.5% [95% confidence interval (CI) = 71.8-85.2%] in the DOT group versus 61.8% in the SAT group (95% CI = 55.0-68.6%); differences were driven by DOT effects in the first 6 weeks. CO-verified abstinence did not differ between groups during the intervention (P = 0.26), but was higher in the DOT than the SAT group at intervention end (DOT = 18% versus SAT = 10%, difference = 8%, 95% CI = -13, 28); this difference was not significant (P = 0.39) and was not sustained at 24-week follow-up.Among daily smokers attending opioid treatment programs, opioid treatment program-based varenicline directly observed therapy was associated with early increases in varenicline adherence compared with self-administered treatment, but findings were inconclusive as to whether directly observed therapy was associated with a difference in tobacco abstinence." @default.
• W3082523213 created "2020-09-08" @default.
• W3082523213 creator A5028743057 @default.
• W3082523213 creator A5029592159 @default.
• W3082523213 creator A5064208076 @default.
• W3082523213 creator A5078185186 @default.
• W3082523213 creator A5082330971 @default.
• W3082523213 date "2020-10-13" @default.
• W3082523213 modified "2023-10-16" @default.
• W3082523213 title "Effect of varenicline directly observed therapy versus varenicline self‐administered therapy on varenicline adherence and smoking cessation in methadone‐maintained smokers: a randomized controlled trial" @default.
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• W3082523213 doi "https://doi.org/10.1111/add.15240" @default.

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